Fe_2O_3纳米磁流体热疗治疗小鼠结肠癌实验研究  

Anticancer Effect of Hyperthermia with Magnetic Nanoparticles Fe_2O_3 Colon Cancer

作　　者：尹燕鹰[1] 高嫦娥[1] 陈明清[1] 顾宁[2] 董坚[1] 

机构地区：[1]昆明医学院第一附属医院生物治疗中心,650032 [2]东南大学生物材料与器件重点实验室

出　　处：《医学研究杂志》2012年第12期114-117,共4页Journal of Medical Research

摘　　要：目的研究Fe2O3纳米磁流体热疗对小鼠结肠癌的治疗效果。方法磁流体直接局部注射到小鼠皮下肿瘤组织,交变磁场下加热至43℃,计算瘤体积抑制率,肿瘤组织及各个脏器做病理检测。结果 Fe2O3纳米磁流体在交变磁场(alternatingmagnetic field,AMF)中升温迅速。热疗组相比磁流体对照组、磁场对照组、空白对照组,热疗6天后瘤体体积抑制率分别为50.87%、50.50%、76.57%,P<0.05,差异有统计学意义。病理检测证实肿瘤组织部分凋亡,而正常脏器无变化。结论 Fe2O3纳米磁流体热疗可抑制小鼠结肠癌的增长,对结肠癌的治疗有一定作用,但并不能完全抑制肿瘤的生长。实验证明热疗安全可靠。Objective To research hyperthermia effect of the magnetic nanoparticles（ Fe2O3 ） for mice colon cancer. Methods Magnetic nanoparticles was targeted to be injected into the subcutaneous tumor. Magnetic nanoparticles were heated to 43 ℃ in the alterna- ting magnetic field. Tumor sizeinhibition rate was calculated, and tumor tissue and organs undorwent pathology testing. Results Fe2O3 nano magnetic in alternating magnetic field was rapidly heated. Compared with the MF group, the AMF group, the blank control group, in the sixth day later heated, the inhibition rate to the volume were 50.87% , 50.50% and 76.57% respectively（ P 〈 0.05 ）. Pathology tes- ting proved that tumor tissue appeared part of apoptosis and normal organs did not change. Conclusion By magnetic nano Fe2O3 hyper- thermia could restrain the growth of the colon cancer in mice. Treatment had certain effect for colon cancer, but hyperthermia could not completely inhibited the growth of tumors. Experiments show that hyperthermia was safe and reliable.

关 键 词：磁流体 交变磁场 热疗 结肠癌 

分 类 号：R273.733[医药卫生—中西医结合]