戊羟利定的药动学研究及进展  

Study on pharmacokinetics of penehyclidine

作　　者：刘扬[1] 丁国华[1] 冯克玉[1] 刘大洋[1] 孙艳[1] 王玉娟[1] 

机构地区：[1]黑龙江省第二医院黑龙江省中毒抢救治疗中心,黑龙江哈尔滨150010

出　　处：《中国工业医学杂志》2012年第6期428-431,共4页Chinese Journal of Industrial Medicine

基　　金：黑龙江省自然科学基金项目"常见特殊解毒药的药动学研究"(编号D201142)

摘　　要：收集近年国内外戊羟利定药动学研究有关文献,对戊羟利定在动物和人体的药动学实验研究成果、临床应用现状和存在的问题进行综合性总结分析,探讨如何利用其药动学规律提高临床合理用药水平。戊羟利定及其各光学异构体在动物和人血中消除缓慢,易在组织中分布,给药剂量大或连续给药时易在体内蓄积且维持较高血药浓度;提出根据其药动学规律确定给药间隔及给药剂量的方法,为临床医生合理应用戊羟利定提供科学依据,也为戊羟利定药动-药效学的深入研究提供基础。戊羟利定在救治有机磷中毒时,合理设置戊羟利定给药时机和剂量是解毒成功的关键,利用药动学研究成果可为其临床合理应用提供参考,从而可最大限度地发挥药效,减少毒副作用。Collect recent references involved pharmacokinetic, laboratory and clinical studies on penehyclidine, make comprehensive analysis to explore its pharmacokinetic patterns. The results showed that elimination of penehyclidine and its optical isomers from blood are quite slow both in animals and human bodies, and easily distribute in tissues, therefore, large dose or continuous administration of penehyclidine would be easy to accumulate in the body and could maintain higher plasma concentrations for a longer time. Thereby, a suggestion was raised naturally that smaller dosage and longer intervals should be reasonable according to its pharma- cokinetic rule, which provides a scientific basis for the scientific and safe application of penehyclidine in clinical practice. The references suggested that the scientific administration interval and dose of penehyclidine is critical for the treatment of organic phosphorus poisoning. The establishment of pharmacokinetic/pharmacodynamic model can provide an accurate basis for the administration time and dose in clinical use, which could provide maximum efficiency and minimal side-effect.

关 键 词：戊羟利定 药动学 剂量 药动-药效模型 

分 类 号：R971.92[医药卫生—药品]