移植肾穿刺活检60例的病理学研究  

Pathological analysis of 60 cases of renal allograft biopsy

作　　者：隋燕霞[1] 王凯[1] 侯军[2] 李晓峰[1] 杨喆[1] 

机构地区：[1]西安交通大学医学院第一附属医院病理科,西安710061 [2]西安交通大学医学院第一附属医院肾移植科,西安710061

出　　处：《安徽医科大学学报》2013年第1期50-52,共3页Acta Universitatis Medicinalis Anhui

基　　金：陕西省科技计划项目(编号:2009K17-04)

摘　　要：目的研究移植肾在术后出现合并症时,经皮肾穿刺活检的病理形态学特点,探讨穿刺活检的诊断意义。方法参照Banff 2005和Banff 1997移植肾活检病理学诊断与分类方案对60例移植肾的穿刺活检标本进行病理学诊断和分类。结果 60例移植肾穿刺活检标本中急性排斥反应17例(28.3%)、慢性排斥反应21例(35.0%)、界线性病变9例(15.0%)、复发或新发性肾病6例(10.0%),急性肾小管损伤5例(8.3%)、药物毒性反应2例(3.3%)。结论移植肾穿刺活检的病理学观察可以及时准确地诊断肾移植术后的多种合并症,是一种安全有效的诊断手段。Objective To investigate the pathological changes of renal allografts through percutaneous renal biopsy when complications happened after the kidney transplant.Methods Speciments of 60 cases of percutaneous renal biopsy were pathological diagnosed and classified according to Banff 2005 and Banff 1997 standards.Results 17 of 60 allografts demonstrated acute rejection.21 cases showed chronic rejection.Borderline changes were found in 9 of 60 cases.Recurrent or de novo diseases were seen in 6 cases.5 cases showed acute nephric tubule damage and 2 cases demonstrated secondary reaction to drug toxicity.Conclusion Pathological observation throught percutaneous renal biopsy after the kidney transplant may be helpful in making the prompt and accurate diagnosis of multiple transplant complications.It is a safe and effective diagnosis approach.

关 键 词：肾移植 活检 病理诊断 

分 类 号：R446.8[医药卫生—诊断学]