关于临产前后胎盘与胎膜中细胞凋亡的研究  

Study on Cellular Apoptosis in Placentas and Fetal Membranes Before and After Labour

作　　者：李小毛[1] 沈慧敏[1] 侯红瑛[1] 范建辉[1] 彭晓谋[2] 

机构地区：[1]中山医科大学附属第三医院妇产科,广州510630 [2]中山医科大学附属第三医院传染科,广州510630

出　　处：《中华围产医学杂志》2000年第2期71-73,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨胎盘与胎膜中细胞凋亡与分娩发动的关系。　方法　对 18例未临产剖宫产和 19例顺产病例的胎盘与胎膜组织 ,应用 TU NEL 法检测凋亡细胞 ,并计算出凋亡指数。　结果　未临产组与临产组羊膜上皮细胞、绒毛膜滋养细胞、胎盘绒毛滋养细胞及蜕膜的细胞凋亡指数分别为(2 5 .49± 1.72 ) %与 (33.78± 1.33) %、(2 6 .74± 2 .0 5 ) %与 (36 .32± 1.96 ) %、(41.0 6± 1.96 ) %、与(49.12± 2 .5 5 ) %、(32 .6 9± 2 .2 7) %与 (38.6 2± 2 .2 5 ) % ,两组之间差异有极显著性 (P<0 .0 1)。　结论　分娩发动可能与胎盘和胎膜组织中的细胞凋亡指数增加有关。Objective To study the relationship between the onset of labor and the cellular apoptosis in placentae and fetal membranses. Methods The TUNEL method was used to detect apoptosis in placentae and fetal membranes, which were taken from 18 elective caesarean sections and 19 vagingal deliveries. The apoptotic index(AI)was calculated. Results The AIs in the amnion epithelial , chorionic throphoblast,placental throphoblast and decidual in the elective caesarean section group and vaginal delivery group were (25.49±1 72)% and (33 78±1 33)%,(26 74±2 05)% and (36 32±1 96)%,(41 06±1 96)%,and (49 12±2 55)%,(32 69±2 27)% and (38 62±2 25)%, respectively. The AIs in the vaginal delivery group were significantly higher than that in the elective caesarean setion group (P<0.01). Conclusions The onset of labour significantly increases the AIs in placentae and fetal membranes.

关 键 词：胎盘 胎膜 脱噬作用 分娩发作 细胞凋亡 

分 类 号：R715[医药卫生—妇产科学]