μ阿片受体在大鼠腹主动脉、心脏和肾脏的分布和定位  

Distribution and localization of μ opioid receptor in the abdominal aorta,heart and kidney of rats

作　　者：白三省[1] 陈文生[1] 杨阳[1] 金振晓[1] 

机构地区：[1]第四军医大学西京医院心脏外科,西安710032

出　　处：《中国体外循环杂志》2012年第4期239-242,共4页Chinese Journal of Extracorporeal Circulation

摘　　要：目的观察μ阿片受体(MOR)在正常大鼠腹主动脉、心脏和肾脏组织中的分布和定位。方法选用成年SD大鼠腹主动脉、心脏和肾脏冰冻切片进行免疫组织化学染色,对MOR在大鼠心脏、大动脉和肾脏的分布进行定位分析。结果MOR免疫阳性物质主要分布于腹主动脉内皮层和肾小球毛细血管内皮,而在心脏未发现。结论 MOR在大鼠腹主动脉内皮和肾小球毛细血管内皮有分布。Objective To investigate the distribution of μ opioid receptor （MOR） in the abdominal aorta, heart and kidney of normal Sprague - Dawley rats. Methods Immunohistochemistry （IHC） technique was used to detect the μ opioid receptor in the frozen sections of the heart, abdominal aorta and kidney tissues of normal Sprague - Dawley rats. Results μ opioid receptors were detected in the endothelial cells of abdominal aorta, the capillaries of the glomerulus, but not in the endocardium. Conclusion μ opioid receptors exist in the abdominal aorta and kidney of rats.

关 键 词：Μ阿片受体 内吗啡肽 免疫组织化学 SD大鼠 

分 类 号：R654.1[医药卫生—外科学]