胰岛素强化治疗早期糖尿病视网膜病变患者对比敏感度与眩光功能的变化  

Changes in contrast sensitivity and glare sensitivity after intensive glucose control with insulinin diabetic patients

作　　者：陈镇国[1] 陈嘉玮[1] 林思思[1] 钟洪亮[1] 张加裕[1] 田蓓[2] 

机构地区：[1]温州医学院附属第三医院眼科,瑞安325200 [2]首都医科大学北京同仁医院眼科中心北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼视光学与视觉科学杂志》2012年第12期753-756,共4页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：浙江省科技计划项目（2009C33169）

摘　　要：目的探讨胰岛素强化治疗后早期糖尿病视网膜病变（DR）患者对比敏感度与眩光敏感度的变化。方法前瞻性系列病例研究。纳入进行胰岛素强化治疗的糖尿病视网膜病变患者54例（108眼），利用Takagi CGT-1000自动GS检查仪对所有患者的对比敏感度和眩光敏感度进行6个月随访．随访时间点分别为强化治疗前和强化治疗后3个月、6个月。采用重复设计的方差分析和LSD法两两比较分析治疗前后对比敏感度和眩光敏感度变化。结果强化治疗后3个月对比敏感度在6．3°、2．5°、1．6°、1．0°高于治疗前，差异有统计学意义（t=2．521、3．298、2．808、3．275，P均〈0．05）；治疗后6个月，对比敏感度在2．5。和1．0。高于治疗前，差异有统计学意义（t=2．096、2．059，P均〈0．05）。治疗后6个月较治疗后3个月各频段差异并无明显统计学意义。强化治疗后3个月和6个月，眩光敏感度各频率段较治疗前均有升高，但是差异均无统计学意义（F值分布于1．092-3．046，P值均〉0．05）。结论胰岛素强化治疗短期内能一定程度改善视功能，延缓早期糖尿病视网膜病变患者视功能损害的进展。Objective To study the changes in contrast sensitivity and glare sensitivity after intensive glucose control during a six-month follow-up period. Methods In a prospective case series study, 108 eyes of 54 patients who underwent intensive glucose control treatment were included in this study. The Takagi CGT-1000 was used to obtain contrast sensitivity and glare sensitivity for the eyes of all patients. Measurements were taken at pre-treatment, 3 and 6 months after intensive glucose control. The repeat measurement ANOVA and the least-significant difference （LSD） pairwise were used for statistical comparison and data analysis. Results Contrast sensitivity： contrast sensitivities at 6.3°, 2.5°, 1.6° and 1.0° 3 months after intensive glucose control were higher than those before treatment （t=2.521, 3.298, 2.808, 3.275, P〈0.05）; contrast sensitivities at 2.5° and 1.0° 6 months after intensive glucose control were higher than those before treatment （t=2.096, 2.059, P〈0.05）. There was no significant difference in contrast sensitivity at each frequency between 3 months and 6 months. Glare sensitivity： Glare sensitivities at low, moderate and high frequencies 3 months and 6 months after intensive glucose control were higher than those before treatment. However, there was no statistically significant difference at each frequency between the pre-treatment and post-treatments （F ranged from 1.092 to 3.046, P〉0.05）. Conclusion Intensive glucose control can improve visual function for the short term and may delay the progress of visual function damage in the early stage of diabetic retinopathy.

关 键 词：胰岛素强化治疗 对比敏感度 糖尿病视网膜病变 眩光 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]