超声靶向破坏微泡介导基因或药物抗血管再狭窄的研究进展  

Ultrasound-targeted Microbubble Destruction Mediate Gene or Drug Therapy for Vascular Restenosis

作　　者：金琳 杜联芳[2] 

机构地区：[1]上海市嘉定区中心医院超声科,上海市201800 [2]上海交通大学附属第一人民医院超声科,上海市200080

出　　处：《中国动脉硬化杂志》2012年第12期1149-1152,共4页Chinese Journal of Arteriosclerosis

摘　　要：血管成形术是治疗狭窄或闭塞性血管疾病的主要方法之一,而术后的再狭窄影响其远期疗效,预防再狭窄一直是心血管疾病的重要课题。超声靶向破坏微泡技术使携带的基因或药物在靶组织定向释放,使局部浓度大大增高,从而达到靶向治疗目的,为抗再狭窄提供了新的方法。现对超声靶向破坏微泡介导基因或药物治疗的原理及在抗血管再狭窄中的研究现状及应用前景作一综述。Angioplasty treatment is one of the main methods for narrow or occlusive vascular disease, but restenosis affects the long-term effect. Prevent vascular restenosis has been an important subject in cardiovascular diseases. Ultra- sound-targeted microbubble destruction can deliver gene or drug to the points of interest in the body, which can enhance the concentration of the gene or drug, enhance efficacy cure effects, and provide a new method for restenosis. In this review, we will introduce the theory of gene or drug therapy mediated by ultrasound-targeted microbubble destruction, and its pros- pects in vascular restenosis.

关 键 词：超声造影剂 微泡 血管再狭窄 基因治疗 药物治疗 

分 类 号：R540.4[医药卫生—心血管疾病]