南昌市2010年初不同人群肠道病毒71型血清流行病学调查  

Seroepidemiology investigation on HEV71 in the population in Nanchang in early 2010

作　　者：熊英[1] 龚甜[1] 施勇[1] 周珺[1] 刘丽萍[1] 曾艳文[1] 刘师文[1] 肖芳[1] 

机构地区：[1]江西省疾病预防控制中心,江西南昌330029

出　　处：《现代预防医学》2013年第1期7-10,共4页Modern Preventive Medicine

基　　金：江西省卫生厅科技计划(20092005)

摘　　要：目的了解2010年初江西省南昌市人群人肠道病毒71型(Human Enterovirus71,HEV71)抗体水平,为预防控制手足口病(Hand-foot-mouth Disease,HFMD)在人群中的流行提供依据。方法选择江西省甲型H1N1流感感染状况快速血清学调查的1144份血清标本,采用中和试验检测血清HEV71中和抗体,并对检测结果进行统计学分析。结果 HEV71中和抗体阳性率为74.74%(855/1144),2岁～组儿童抗体阳性率最低,随着年龄的增长,抗体阳性率升高,3岁以下儿童中和抗体阳性率仅为52.01%;HEV71中和抗体阳性标本的几何平均滴度为1︰22.34,以0岁～组GMT最低,3岁～组达到高峰,之后呈下降趋势;不同月龄婴儿HEV71中和抗体阳性率0～月龄最高,之后逐月下降,至4～月龄组阳性率最低,之后开始升高,EV71阳性标本中和抗体几何平均滴度0～月龄组GMT与1～月龄组基本持平,之后逐月下降,5～月龄组最低,6～月龄组急剧升高;在HEV71中和抗体阳性人群中,各年龄组中中和抗体滴度1︰8～1︰32构成比均为显著高于其他滴度组构成比(P﹤0.05),滴度≥1︰256的标本从6～月龄组开始,各年龄组均有出现。结论南昌市人群HEV71中和抗体水平较高,各年龄组人群近期均有感染,3岁以下儿童是HEV71感染引起HFMD流行的最易感人群,学龄前儿童是HFMD流行防控的重点,成人也应预防HEV71的感染;胎儿具有母传抗体,但抗体水平降低较快。OBJECTIVE To understand Human Enterovirus 71 （HEV71） antibody levels in the population in Nanchang, Jiangxi Province, early 2010, to find the epidemic status of hand, foot and mouth diseases （HFMD）, and to provide a scien- tific base for the HFMD prevention and control. METHODS 1 144 sera specimens proposed to be detected for rapid serological survey of H1N1 influenza infection in Jiangxi in early 2010. HEV71 antibodies were detected by using neutralization test, and then the results were analyzed by statistic methods. RESULTS The positive rate of HEVT1 neutralizing antibody was 74.74% （855/1 144）, 2-year-old group had the lowest rate of positive antibody. Positive antibody rate increased with the age increas- ing. The positive antibody rate in under 3-year-old children group was 52.01%. Geometric mean titer （GMT） of positive sam- ples of HEV71 neutralizing antibody was 1 ： 22.34. 0-year-old group had the lowest GMT and 3-year-old group reached a peak, then declined; Among different months old babies, positive rate of HEVT1 antibody was the highest in 0-month-old, then declined with month increasing, and the lowest in 4-month-old, then rose. GMT of positive samples of HEV71 neutraliz- ing antibody was similar between 0-month old group and 1-month old group, then declined monthly and reached the lowest in 5-month-old group, increased sharply in 6-month-old group; The proportions of the neutralizing antibody titer 1 ： 8-1 ： 32 group in all age groups were significantly higher than other HEV71 positive neutralizing antibody groups （P 〈 0.05 ）. The titer of 〉 1 ： 256 emerged from 6-month-old group, and existed in all age groups. CONCLUSION HEV71 neutralizing antibody level is high in the population in Nanchang, each age group is infected recently. Children under 3 years old are the most susceptible to HEVT1.Preschool children are the focus of HFMD epidemic prevention and control. Adults should also prevent to be infected by HEV71. Newborn fetus hold maternal HEV71 antibodies, but antib

关 键 词：人肠道病毒71型 中和抗体 血清流行病学调查 

分 类 号：R181.3[医药卫生—流行病学]