鼻咽癌患者血清中TK1的检测意义  

The application of serum thymidine kinase 1 level changes in patients with carcinoma of nasopharynx

作　　者：唐梦君[1] 胡望远[1] 

机构地区：[1]浙江省金华市中心医院放疗科,浙江金华321000

出　　处：《中国现代医生》2012年第34期57-58,共2页China Modern Doctor

基　　金：浙江省金华市科学技术研究计划项目(2010-3-060)

摘　　要：目的探讨血清细胞质胸苷激酶1(TK1)在鼻咽癌患者的诊断及治疗后效果评估中的意义。方法应用免疫印迹增强化学发光法检测30例对照组(包括15例鼻咽部炎症患者和15例正常体检者)和30例初治鼻咽癌患者治疗前及治疗后的血清中TK1浓度,分析治疗前后鼻咽癌患者TK1水平变化。结果鼻咽癌患者治疗前血清TK1水平明显高于健康对照组,TK1水平与鼻咽癌分期有明显相关性,而与淋巴结是否转移无明显相关性;鼻咽癌患者治疗后TK1水平明显低于治疗前。结论血清TK1检测对鼻咽癌患者的临床诊断及疗效评价具有一定的临床应用价值。Objective To evaluate the serum thymidine kinase 1（TK1） levels as a tumor marker for early diagnosis, clinical stages and clinical value of therapy in patients with carcinoma of nasopharynx. Methods Serum samples were collected from 30 patients with carcinoma of nasopharynx, 15 with nasopharyngitis and 15 normal controls, the serum samples were analyzed by the enhanced chemi-luminescence assay. Results The TK1 levels in patients with carcinoma of nasopharynx were much higher than those in participants with nasopharyngitis and normal controls （P 〈 0.01）; the serum TK1 levels were associated with the carcinoma of nasopharynx stages, but not with the lymph node metastasis. The TK1 levels between patients with nasopharyngitis and normal controls were no significant difference. Conclusion The detection of TK1 can re- flect cell proliferation, and may have value in the diagnosis, monitoring and prognosis of carcinoma of nasopharynx.

关 键 词：鼻咽癌 TK1 诊断 

分 类 号：R713.4[医药卫生—妇产科学]