全麻诱导期舒芬太尼分两次外周静脉注射对其诱发呛咳反应的影响  

Effects of sufentanil administration divided into two times through peripheral vein for inhibiting sufentanil-induced bucking during anesthesia induction

作　　者：宗志军[1] 王义桥 

机构地区：[1]安徽医科大学第一附属医院麻醉科,安徽合肥230022

出　　处：《安徽医药》2012年第12期1849-1850,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察全身麻醉诱导期舒芬太尼分两次外周静脉注射对其诱导期诱发呛咳反应的影响。方法 100例25～55岁ASA分级Ⅰ～Ⅱ级的择期行腹部手术患者随机为观察组和对照组:50例在全身麻醉诱导时先静注0.2μg·kg-1舒芬太尼,1min后按顺序静注咪达唑仑0.05 mg·kg-1、舒芬太尼0.3μg·kg-1、依托咪酯0.2 mg·kg-1、维库溴铵0.1 mg·kg-1(观察组,n=50);50例在全麻诱导期一次性静脉注射舒芬太尼诱导期给药总量的给药组(对照组,n=50),即在全身麻醉诱导期按顺序静注咪达唑仑0.05 mg·kg-1、舒芬太尼0.5μg·kg-1、依托咪酯0.2 mg·kg-1、维库溴铵0.1 mg·kg-1;两组患者舒芬太尼的静脉注射速度相同,总的诱导期舒芬太尼的静注时间均在5 s内。对比两组患者诱导期呛咳发生率和强度。结果观察组患者诱导期呛咳显著低于对照组,且发生同级别呛咳的人数显著少于对照组。结论全身麻醉诱导期分两次外周静脉注射舒芬太尼能显著降低舒芬太尼诱导期的呛咳反应。Objective To observe the effects of sufentanil administration divided into two times through peripheral vein for inhibiting sufentanil-induced bucking during anesthesia induction.Methods A hundred cases 25-55 years old,ASA scheduled Ⅰ～Ⅱ,undergoing elective abdominal surgery were randomly divided into the observation group and control group with 50 cases in each group：each patient in observation group was given 0.2 μg·kg-1 sufentanil beforehand,and then given midazolam 0.05 mg·kg-1,sufentanil 0.3 μg·kg-1,etomidate 0.2 mg·kg-1,vecuronium bromide 0.1 mg·kg-1 during anesthesia induction in order one minute later（observation group,n=50）;each patient in control group was given midazolam 0.05 mg·kg-1,sufentanil 0.5 μg·kg-1,etomidate 0.2 mg·kg-1,vecuronium bromide 0.1 mg·kg-1 during anesthesia induction in order（control group,n=50）,and the total amount of 0.5 μg·kg-1 sufentanil which was given during anesthesia induction was injected intravenously within five seconds.The incidence and degree of bucking after the injection of sufentanil were evaluated during anesthesia induction.Results The incidence of bucking in the observation group was significantly lower than that in the control group,and there was statistical significance（P0.05）.Conclusion Administration of sufentanil divided into two times through peripheral vein can effectively reduce the incidence of sufentanil-induced bucking during anesthesia induction.

关 键 词：全麻诱导期 舒芬太尼 呛咳 

分 类 号：R614[医药卫生—麻醉学]