外用钙泊三醇倍他米松软膏和0.05%他扎罗汀凝胶治疗斑块型银屑病的比较  

Comparative study of calcipotriol/betamethasone dipropionate ointment and 0.05% tazarotene gel in the treatment of stable plaque psoriasis

作　　者：张弛[1] 何健[1] 胡白[1] 

机构地区：[1]安徽省立医院皮肤科,安徽合肥230001

出　　处：《安徽医药》2012年第12期1851-1853,共3页Anhui Medical and Pharmaceutical Journal

基　　金：中华医学会皮肤性病学分会励奥皮肤病学研究基金

摘　　要：目的比较钙泊三醇倍他米松软膏与0.05%他扎罗汀凝胶治疗斑块状银屑病的疗效与安全性。方法对收集的32例斑块型银屑病患者进行临床观察研究,患者在对称性皮损部位分别外用钙泊三醇倍他米松软膏和0.05%他扎罗汀凝胶,治疗1、2、4周后比较疗效和安全性。结果治疗后1周和2周,钙泊三醇倍他米松软膏疗效优于0.05%他扎罗汀凝胶,差异有显著性(P<0.05)。治疗后4周,钙泊三醇倍他米松软膏疗效与0.05%他扎罗汀凝胶相近,差异无显著性(P>0.05)。两组有效率分别为71.86%和68.75%,差异无显著性(P>0.05)。结论钙泊三醇倍他米松软膏和0.05%他扎罗汀凝胶治疗斑块状银屑病安全有效,治疗早期钙泊三醇倍他米松软膏可能起效更快。Objective To observe the efficacy and safety of calcipotriol/ betamethasone dipropionate ointment and 0.05% tazarotene gel in the treatment of plaque-type psoriasis.Methods Thirty-two patients with plaque-type psoriasis were enrolled in clinical trial.All patients were treated with calcipotriol/betamethasone dipropionate ointment and 0.05% tazarotene gel respectively in symmetrical lesions.Evaluation was done at baseline（0 week）,1 week,2 weeks and 4 weeks of treatment.Results After 1-week and 2-week treatment,the plaque improvement by using topical calcipotriol betamethasone dipropionate ointment was more than that by using 0.05% tazarotene gel（P0.05）.At the end of 4 weeks,improvement by using topical calcipotriol/betamethasone dipropionate ointment was comparable to that by using 0.05% tazarotene gel（P0.05）.75 percent decrease in PASI was observed in 23（71.86%）patients receiving combination therapy and 22（68.75%）patients receiving monotherapy with no difference between the two groups（P0.05）.Conclusions Calcipotriol/betamethasone dipropionate ointment and 0.05% tazarotene gel are safe and effective in therapy for plaque type psoriasis.Combined ointment may be more effective in early stage of treatment.

关 键 词：钙泊三醇 倍他米松 他扎罗汀 银屑病 药物评价 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]