胸腔注入尿激酶治疗结核性胸膜炎的疗效观察  

Effect of intrapleural injection with urokinase in treatment of tuberculous pleuritis

作　　者：王卫阳 

机构地区：[1]安徽省胸科医院,安徽合肥230022

出　　处：《安徽医药》2012年第12期1863-1864,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨胸腔内注射尿激酶治疗结核性胸膜炎的临床疗效。方法将90例结核性胸膜炎患者随机分为两组,治疗组45例,用0.9%氯化钠注射液10 ml加尿激酶10万U于每次抽液后行胸腔内注射;对照组45例,用0.9%氯化钠注射液10 ml加异烟肼0.1 g于每次抽液后行胸腔内注射,治疗结束后进行比较,观察两组的导管留置时间、胸膜厚度、胸水吸收以及胸膜黏连情况。结果治疗组的疗效明显优于对照组,差异有统计学意义。结论胸腔内注射尿激酶能够促进胸腔积液吸收,使胸膜肥厚减轻、黏连减少,可以缩短静脉导管在胸腔内留置时间;该方法不良反应较少,操作简单,值得临床推广应用。Objective To investigate the effects of intrapleural injection with urokinase in prevention and treatment of tuberculous pleuritis.Methods Eighty patients with tuberculous pleuritis were divided into two groups by random allocation.Therapeutic group of 40 cases received intrapleural injection with urokinase 104 U added into 0.9 % sodium chloride injection 20 ml after each thoracic drainage,and control group of 40 cases received intrapleural isoniazid 0.1 g injection added into 0.9% sodium chloride injection 20 ml after each thoracic drainage.After the end of treatment we compared catheter detaining time,pleural thickness,chest water absorption and pleural adhesion of the two groups.Results The curative effect was significantly lower in therapeutic group than control group.Conclusions Intrapleural injection with urokinase has certain prevention and treatment in pleural thickening and adhesion due to tuberculous pleuritis.There is no obvious adverse reaction.It has the advantage of simple operation,which is worthy of clinical application.

关 键 词：结核性胸膜炎 尿激酶 胸膜黏连 

分 类 号：R521.7[医药卫生—内科学]