135例药源性死亡病例统计分析  

Analysis of 135 cases with drug-induced death

作　　者：姚宏[1] 

机构地区：[1]安徽省宣城市人民医院药剂科,安徽宣城242000

出　　处：《安徽医药》2012年第12期1895-1897,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨药源性死亡患者临床用药特点,为降低患者用药风险提供参考。方法检索2005—2011年《中国医院数字图书馆》和《万方数据库》中有关药物致死病例,分析患者用药种类、给药途径及直接死亡原因等。结果 135例药源性死亡病例中,呼吸系统疾病(54例,40.00%)、循环系统疾病(42例,31.11%)、消化系统疾病(11例,8.15%)为致死患者主要原发疾病;抗菌药物(40例,29.63%)、中药注射剂(27例,20.00%)、心血管药物(15例,11.11%)和中枢神经系统药物(14例,10.37%)为主要致死药物;静脉滴注(51例,37.78%)、口服(47例,34.81%)和静脉推注(17例,12.60%)为致死患者主要给药途径;变态反应(67例,49.63%)为主要直接死亡原因。结论抗菌药物、中药注射剂、心血管药物和中枢神经系统药物最容易出现致死,尤其静脉滴注时风险最高,医务人员要重视用药过程中出现的变态反应。Objective To provide reference data which can reduce medication risk by discussing the regularity of drug-induced deaths.Methods The case reports on drug-induced deaths were studied in China Hospital Knowledge Database and Wanfang Med Online from 2005 to 2011.Results Among the deaths,respiratory,circulatory and digestive system diseases whose cases were respectively 54,42 and 11 were the main primary diseases.Antibiotics,traditional Chinese medicine,cardiovascular drugs and central nervous system drugs were the leading causes of death.The cases were respectively 40,27,15,and 14.The proportion were respectively 29.63%,20.00%,11.11% and 10.37%.Allergic reaction was the most common direct cause of death cases,which had 67 cases and accounted for 49.63%.Conclusions Antibiotics,traditional Chinese medicine,cardiovascular drugs and central nervous system drugs were the leading causes of death,especially intravenous drop infusion.

关 键 词：药源性死亡 不良事件 变态反应 

分 类 号：R595.3[医药卫生—内科学] R195[医药卫生—临床医学]