血浆可溶性血小板膜糖蛋白Ⅴ与冠心病的相关性分析  

The relationship of soluble platelet glycoprotein Ⅴ with coronary heart disease

作　　者：许海峰[1] 杨向军[1] 贺永明[1] 赵欣[1] 李勋[1] 

机构地区：[1]苏州大学附属第一医院心内科,苏州215006

出　　处：《南通大学学报（医学版）》2012年第6期461-463,共3页Journal of Nantong University(Medical sciences)

基　　金：江苏省医学领军人才基金资助项目(LJ201140)

摘　　要：目的:检测冠心病(coronary heart disease,CHD)患者血浆可溶性血小板糖蛋白Ⅴ(soluble platelet glycoproteinⅤ,sGPⅤ)的变化,探讨其与CHD的相关性。方法:用酶联免疫吸附试验(enzyme-linked immunosorbnent assay,ELISA)法分别测37例行冠脉造影患者的sGPⅤ水平,Gensini积分评价冠脉病变程度,进行统计学分析。结果:随着Gensini积分的增高,sGPⅤ质量浓度逐渐增高,两者呈正相关(r=0.948,P<0.01)。结论:sGPⅤ在冠脉病变患者中增高,对冠脉的严重程度有预测作用。Objective： To explore the change of soluble platelet glycoprotein Ⅴ（sGPⅤ） in coronary heart disease（CHD） and the the clinical significance.Methods： sGPⅤ was measured by enzyme-linked immunosorbnent assay（ELISA） in 37 patients with CHD.Gensini integral evaluates the degree of coronary artery lesions.We did statistic analysis with SPSS.Results： With the Gensini integral increases,concentration of sGPⅤ increases.Both were positively correlated（r=0.948,P0.01）.Conclusion： sGPⅤ increases in coronary artery disease patients,and it can predict coronary severity.

关 键 词：冠状动脉粥样硬化性心脏病 血小板膜糖蛋白Ⅴ 酶联免疫吸附试验 

分 类 号：R541.4[医药卫生—心血管疾病]