长乐市结核分枝杆菌耐药情况分析  

Resistance of Mycobacterium tuberculosis isolated from Changle

作　　者：林萍[1] 潘洁茹[1] 林建[2] 叶海梅[1] 潘珍瑜[1] 周秀锦 林至云 郑能雄[1] 

机构地区：[1]福建省福州市疾病预防控制中心,福州350004 [2]福建省疾病预防控制中心,福州350001 [3]福建省长乐市疾病预防控制中心,福建长乐350200

出　　处：《中国卫生检验杂志》2012年第12期3011-3013,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解长乐市肺结核病人对一线抗结核药物的耐药情况,为耐药结核病防治提供依据。方法:采用WHO/IUATLD推荐的比例法,对研究对象进行利福平(RFP)、异烟肼(INH)、链霉素(SM)和乙胺丁醇(EMB)的药物敏感实验。结果:68例痰标本中检出67株结核分枝杆菌(MTB),1株非结核分枝杆菌(NTM);67株MTB对4种一线抗结核药物的总耐药率为19.4%,初始和获得性耐药率分别为17.6%和25%,初始耐药占耐药菌株69.2%;初复治患者均以单耐药为主;总耐多药(MDR)率为3%。结论:长乐市结核病患者耐药情况低于全国水平,以单耐药为主要耐药形式,但初始耐药患者占耐药患者的比例高。Objective：To analyze the resistance of Mycobacterium tuberculosis（MTB） against first-line drugs in Changle city and provide the evidences for MTB prevention and control.Methods： The proportion method recommended by WHO/IUATLD was applied to test the strains′ susceptibility to rifampicin（RFP）,isoniazid（INH）,streptomycin（SM） and ethambutol（EMB）.Results： 67 MTB strains and 1 strain of non-tuberculosis mycobacteria（NTM） were isolated from 68 sputum samples.The total resistance rate to 4 first-line drugs was 19.4%.The primary drug resistance and acquired drug resistance rate were 17.6% and 25%,respectively.Primary drug resistance isolates accounted for 69.2% of all drug resistant strains.Single drug resistant was the main pattern of both treatments.The multi-drug resistance rate（MDR） was 3%.Conclusion： The drug resistance of tuberculosis in Changle city was below the national level,and the main pattern was the single drug resistant.The rate of initial drug resistance was higher.

关 键 词：结核分枝杆菌 药敏实验 耐多药 

分 类 号：R378.911[医药卫生—病原生物学]