抗HIV-1药物及其复方制剂研究新进展  

Progress in Researches on Anti-HIV-1 Drugs and Their Fixed-dose Combination

作　　者：冯婧劼[1] 张庆文[2] 徐云根[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009 [2]上海医药工业研究院化学制药部,上海200437

出　　处：《药学进展》2012年第12期539-546,共8页Progress in Pharmaceutical Sciences

摘　　要：抗HIV-1感染的治疗具有终身性,而目前临床上的抗HIV-1药物在长期使用的情况下会产生副作用并有耐药性问题,故开发作用于新靶点的抗HIV-1药物成为研发的热点。对近几年上市或在研的抗HIV-1药物及其复方制剂进行综述,并对其前景进行展望。The increasing incidence of drug resistance and side effects among the AIDS patients treated with anti-HIV-1 drugs, calls for continuous efforts for the development of new target anti-HIV-1 drugs. This article reviews anti-HIV drugs already launched or still in pipeline and their fixed-dose combination. It also offers some comments regarding the future trend.

关 键 词：抗HIV-1药物 新靶点 耐药性 高效抗逆转录病毒治疗 

分 类 号：R978.7[医药卫生—药品] R914.4[医药卫生—药学]