辛伐他丁与心得安治疗肝硬化门静脉高压症的比较  

Simvastatin D With Propranolol Cirrhosis and Portal Hypertension in Comparison

作　　者：杨玉贵[1] 

机构地区：[1]河南省郑州市第六人民医院肝病三科,河南郑州450015

出　　处：《中外医疗》2012年第34期95-96,共2页China & Foreign Medical Treatment

摘　　要：目的探讨辛伐他汀与普萘洛尔(心得安)治疗肝硬化门静脉高压的临床疗效。方法该院自2008年5月—2012年3月收治60例肝硬化并门静脉高压患者资料,按照患者治疗方式分为对照组和观察组,各30例,两组患者均行常规治疗,观察组患者采用辛伐他汀治疗,对照组患者采用普萘洛尔治疗,连续治疗1个月,比较治疗前后两组患者门静脉血流动力学情况。结果观察组患者门静脉血流动力学参数改善优于对照组,两组患者比较,差异有统计学意义(P<0.05)。结论他汀类药物能改善肝硬化患者肝血管内皮机能,可能成为门静脉高压的有效治疗方法。Objective To investigate the simvastatin and propranolol（Inderal） in the treatment of patients with portal hypertension clinical efficacy.Methods Our hospital from May 2008 to March 2012 treated 60 cases of liver cirrhosis and portal hypertension patients information,in accordance with the patients divided into control group and observation group,30 cases of patients in both groups received conventional treatment,observation group simvastatin treatment and control group were treated with propranolol,continuous treatment for a month,before and after treatment in patients with door venous blood flow mechanics situation.Results The patients portal hemodynamics parameters to improve than the control group,two groups of patients the difference was statistically significant（P0.05）.Conclusion The statins can improve liver vascular endothelial function in patients with cirrhosis may be effective treatment portal hypertension.

关 键 词：辛伐他汀 肝硬化 门静脉高压 普萘洛尔 

分 类 号：R657.34[医药卫生—外科学]