血清转化生长因子-β1在特发性血小板减少性紫癜患儿中的变化及临床意义  

The change and clinical significance of serum transforming growth factor-β1 in young idiopathic thrombocytopenic purpura patients

作　　者：徐宝华[1] 束进[1] 季海娟[1] 康裕斌[1] 朱红英[1] 

机构地区：[1]江苏省镇江市第一人民医院儿科,江苏镇江212002

出　　处：《中国当代医药》2012年第33期54-55,共2页China Modern Medicine

摘　　要：目的探讨血清中转化生长因子-β1(TGF-β1)在特发性血小板减少性紫癜患儿中的变化及临床意义。方法采用双抗体夹心酶联免疫(ELISA)定量测定方法检测17例ITP患儿治疗前后TGF-β1水平、血小板计数的变化,并与16例正常健康儿童血清TGF-β1、血小板计数水平进行比较。结果 ITP患儿血清TGF-β1水平均显著高于正常对照组(P<0.01),ITP患儿治疗前血清TGF-β1水平均高于治疗后(P<0.01);血清TGF-β1高者,治疗过程中血小板计数恢复较慢。相关分析显示:TGF-β1水平与患者血小板计数呈负相关,与骨髓内巨核细胞数呈正相关(均P<0.01)。结论 TGF-β1参与ITP的发病过程,其水平与血小板变化密切相关,可能与机体免疫机制异常有关。Objective To discuss the change and clinical significance of serum transforming growth factor-beta1 （TGF-β1） in young idiopathic thrombocytopenic purpura patients.Methods The levels of TGF-β1 and the the counts of platelet were quantitative detected with double antibody sandwich enzyme linked immune （ELISA） for 17 cases with ITP before and after treatment,and compared with 16 cases of normal healthy children.Results In children with ITP,the levels of serum TGF-β1 were higher than the normal control group significantly （P 0.01）.The levels of serum TGF-β1 were higher in cases before treatment than after treatment （P 0.01）.The counts of platelet recovery is relative slowly through treatment process in those cases with higher levels of serum TGF-β1.Correlation analysis showed that there were negative correlation between the counts of platelet and the level of TGF-β1 （P 0.01） and there were positive correlation between the counts of megakaryocytes and the the levels of TGF-β1 （P 0.01）.Conclusion TGF-β1 participated in the pathogenesis of ITP process,and there are closely relationship between its levels and the counts of platelet.The reason may be that the body＇s immune mechanism is abnormal.

关 键 词：特发性血小板减少性紫癜 转化生长因子-Β1 巨核细胞 儿童 

分 类 号：R725.5[医药卫生—儿科]