Chiral Diamine-catalyzed Asymmetric Aldol Reaction  

作　　者：LI Hui XU Da-zhen WU Lu-lu WANG Yong-mei 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China

出　　处：《Chemical Research in Chinese Universities》2012年第6期1003-1010,共8页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China(No.2010CB833300);the Research Fund for the Doctoral Program of Higher Education,China(No.20090031110019)

摘　　要：A highly efficient catalytic system composed of a simple and commercially available chiral primary diamine（1R,2R）-cyclohexane-1,2-diamine（6） and trifluoroacetic acid（TFA） was employed for asymmetric Aldol reaction in i-PrOH at room temperature.A loading of 10%（molar fraction） catalyst 6 with TFA as a cocatalyst could catalyze the Aldol reactions of various ketones or aldehydes with a series of aromatic aldehydes,furnishing Aldol products in moderate to high yields（up to 99%） with enantioselectivities of up to 99% and diastereoselectivities of up to 99：1.A highly efficient catalytic system composed of a simple and commercially available chiral primary diamine（1R,2R）-cyclohexane-1,2-diamine（6） and trifluoroacetic acid（TFA） was employed for asymmetric Aldol reaction in i-PrOH at room temperature.A loading of 10%（molar fraction） catalyst 6 with TFA as a cocatalyst could catalyze the Aldol reactions of various ketones or aldehydes with a series of aromatic aldehydes,furnishing Aldol products in moderate to high yields（up to 99%） with enantioselectivities of up to 99% and diastereoselectivities of up to 99：1.

关 键 词：Aldol reaction Chiral primary diamine Asymmetric organocatalysis 

分 类 号：TQ655[化学工程—精细化工] O625.42[理学—有机化学]