中药逆转抗肿瘤药物多药耐药性研究进展  

Traditional Chinese Medicine in Reversal of Multi-drug Resistance

作　　者：李学涛[1] 谭静净[1] 喻荣平[1] 贾天柱[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《辽宁中医药大学学报》2013年第1期155-158,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：肿瘤多药耐药(multidrug resistance,MDR)是目前临床化疗失败的主要原因,具有逆转肿瘤MDR的大部分化药毒副作用比较大且效果差,而中药具有安全有效、多靶点且成本低等优势,弥补了化药抗肿瘤MDR的缺点,文章总结了肿瘤MDR产生的经典机理及中药逆转肿瘤MDR的研究进展。Multiple drug resistance（MDR）of cancer cells is one of the main factors resulting in treatment failures.However,the clinical effects of MDR reversal agents are poor with many side effects.Screening MDR reversal agents in traditional Chinese is safe,effective and has multi-targets.In this review,the current research progress on the mechanism of cancer cell MDR and the research situation of its reversion by Chinese herbal medicine were described.

关 键 词：肿瘤 多药耐药 中药 逆转 

分 类 号：R979.1[医药卫生—药品]