花旗泽仁对胰岛素抵抗大鼠脂肪因子的影响Ⅰ  

Influence of HQZR on the Adipocytokines in Insulin Resistance RatsⅠ

作　　者：葛鹏玲[1] 温薇[1] 李冀[1] 马艳春[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2012年第6期29-30,共2页Acta Chinese Medicine and Pharmacology

基　　金：国家科技重大专项重大新药创制(No.2012ZX09103201-018);黑龙江省自然科学基金(No.LC2011C03);黑龙江省教育厅项目(No.11521265);黑龙江省教育厅留学回国人员科技项目择优资助项目(2010年);2009年黑龙江省博士后科学基金(LBH-Z09001);黑龙江中医药大学校基金(200723)

摘　　要：目的:观察花旗泽仁对2型糖尿病胰岛素抵抗(Insulin Resistance,IR)大鼠抵抗素(Resistin)和脂联素(APN)的影响,从脂肪因子角度探讨花旗泽仁改善胰岛素抵抗的作用机制。方法:应用复合脂肪乳复制2型糖尿病胰岛素抵抗大鼠模型,之后给予花旗泽仁进行干预,采用酶联免疫法检测血清中Resistin和APN的浓度。结果:花旗泽仁明显降低了血清Resistin浓度,同时升高了血清APN,差异显著(P<0.01)。结论:花旗泽仁可通过调节血清Resistin和APN浓度而改善2型糖尿病胰岛素抵抗状态。Objective：To Observing the influence of HQZR on adipocytokines in insulin resistance（IR） rats and to discuss the mechanism of HQZR in ameliorating insulin resistance.Method：1.Set up the IR model in rats by oral administrating compound fat emulsion combining injecting small dose of STZ.2.Use different doses of HQZR to treat the IR rats compared with rosiglitazone.3.Observe the differences within each group on the side of adipocytokines.Result：Compared with blank group,remarkably Resistin ascended and APN fell（P0.01）in model group;compared with model group,Resistin in serum fell and APN ascended（P0.01）in HQZR group.Conclusion HQZR can ameliorate IR by regulating the level of Resistin and APN in serum.

关 键 词：胰岛素抵抗 花旗泽仁 抵抗素(Resistin) 脂联素(APN) 

分 类 号：R285.5[医药卫生—中药学]