蓬子菜中活性成分DXG在大鼠体内的药物动力学研究  

Pharmacokinetics of DXG from Galium Verum L. in Rats

作　　者：崔明宇[1] 孙志伟[1] 王艳[1] 王佳瑜[1] 周学刚[1] 马英丽[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2012年第6期47-50,共4页Acta Chinese Medicine and Pharmacology

基　　金：教育部博士点基金(博点类)(No.20112327110006);哈尔滨市科技创新人才研究专项资金项目(No.2010RFXXS024);黑龙江中医药大学新药研究基金(X201001)

摘　　要：目的:研究蓬子菜活性成分DXG在大鼠体内的药物动力学。方法:采用HPLC法测定大鼠血浆中药物浓度,利用3P97药动学软件处理数据。结果:大鼠静脉注射不同剂量DXG后,DXG的血药浓度-时间变化符合二室模型,分布半衰期分别为3.57,3.70,3.48min(RSD2.51%),消除半衰期分别为34.10,37.99,32.98min(RSD6.13%);AUC值分别为53.62,107.74,242.27mg/min/L。结论:不同剂量DXG静脉注射后,在大鼠体内的药物动力学符合二室模型,且在给药剂量内呈线性药动学特征。Objective：To study the pharmacokinetics of DXG from Galium verum L. in rats.Method：The concentrations of in plasma were detected by HPLC method.The pharmacokinetic parameters were calculated by 3P97 program.Result：DXG was administered by intravenous injection at different doses to rats.The kinetic process of DXG in rats in vivo was best fitted to two compartment models.t1/2,α is 3.57,3.70,3.48min,respectively（RSD 2.51%）.t1/2,βis 34.10,37.99,32.98min,respectively（RSD 6.13%）.AUC is 53.62,107.74,242.27mg/min/L,respectively.Conclusion：The results of the compartmental analysis indicate that the kinetic process of DXG in rats in vivo is best fitted to two compartment models.The AUC-dose relations are evaluated to be liner.

关 键 词：蓬子菜 DXG 药物动力学 

分 类 号：R285.5[医药卫生—中药学]