大豆异黄酮对高脂大鼠血脂的影响  

Effect of Soybean Isoflavones on Serum Lipid Level in Hyperlipidemia Rats

作　　者：孙瑞红[1] 李琨[1] 滕文丽[1] 徐冉[1] 王慧慧[1] 刘晓林[1] 王宏倩[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《中医药学报》2012年第6期50-53,共4页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省教育厅科学技术研究项目(No.11531159)

摘　　要：目的:探讨不同剂量的大豆异黄酮(Soy Isoflavones,SI)对高脂大鼠血脂的影响。方法:雄性Wistar大鼠75只,15只作为正常对照组给予基础饲料,其余大鼠给予高脂饲料喂养。高脂喂养4周后采尾静脉血测定总胆固醇(total cholesterol TC),60只大鼠TC值均较喂养前增高,然后随机分为4组,每组15只,分别为:高脂对照组(高脂饲料+0mg/kg/d SI);低剂量SI组(高脂饲料+30mg/kg/d SI);中剂量SI组(高脂饲料+90mg/kg/d SI);高剂量SI组(高脂饲料+270mg/kg/d SI),连续喂养12周。于实验0、4、8、12和16周分别检测上述各组大鼠血清中TC、甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipoprotein,LDL)的水平。结果:高脂喂养四组与正常对照组相比,TC、TG、LDL水平均有升高,差异有统计学意义(P<0.05);中、高剂量SI组可降低血清中TC、LDL(P<0.05),而低剂量SI组对血清中TC、LDL的影响无统计学意义(P>0.05);高剂量SI组可以降低血清中TG(P<0.05);而低、中剂量SI组对血清中TG的影响无统计学意义(P>0.05),并且大豆异黄酮的剂量越高,对高脂大鼠的降脂作用越明显。结论:大豆异黄酮可降低高脂饲养大鼠的TC、TG、LDL,且有剂量依赖性。Objective： To investigate the effect of different dosages of soybean isoflavones on serum lipid level in Hyperlipidemia rats.Methods： 75 male Wistar rats were selected.In the 75 rats,15 were given basal diet as a control group and the remaining rats were given high fat diet.After four weeks of feeding,the animals were divided into four groups randomly based on total cholesterol（TC） value ：high fat diet control group,low dose SI group（high fat diet ＋30mg/（kg·d））,middle dose SI group（high fat diet ＋90mg/（kg·d））,high dose SI group（high fat diet ＋270mg/（kg·d））.Continuous feeding for 12 weeks,the rats serum TC,TG,LDL levels were measured respectively at the 0,4th,8th,12th and 16th week.Results： Compared with the control group,the serum TC,TG and LDL levels were increased in high fat diet group（P0.05）;the serum TC,LDL levels were decreased significantly in middle and high-dose SI group（P0.05）,the low dose SI group had no significant effect on serum TC,LDL（P0.05）;the serum TG level was decreased significantly in high-dose SI group（P0.05）,the low and middle-dose SI group had no significant effect on serum TG（P0.05）.And the more soybean isoflavones were taken by the Hyperlipidemia rats,and the more lipid-lowering effect appeared.Conclusion： Soy isoflavones can reduce the levels of TC,TG,LDL in Hyperlipidemia rats,and its effects are dose-dependent.

关 键 词：大豆异黄酮 胆固醇 甘油三酯 低密度脂蛋白 

分 类 号：R285.5[医药卫生—中药学]