34例神经精神狼疮患者的临床资料分析  

Clinical analysis of 34 patients with neuropsychiatric systemic lupus erythematosus

作　　者：于飞[1] 雷小妹[1] 沈桂芬[1] 凃巍 余意恺[1] 胡绍先[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2012年第6期343-345,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:对神经精神狼疮(NPSLE)患者的临床表现、治疗及预后进行总结。方法:对34例确诊为NPSLE住院患者的临床表现、影像学资料、实验室指标、治疗及预后等临床资料进行回顾性分析。结果:同期住院诊断SLE共818例,诊断NPSLE34例,发病率为4.16%。NPSLE首发症状最常见的是狼疮性头痛(24.2%)、脑血管病变(22.3%),发热(97.1%)及新发皮疹(61.8%)为常见的伴随症状。根据SLEDAI评分,34例患者中76.5%患者处于疾病重度活动期(评分≥15)。结论:NPSLE临床表现多样,2种及以上临床亚型并存者多见。首发症状以狼疮性头痛最常见。颅脑影像学检查在NPSLE的诊断中具有重要意义。Objective ： To summarize the clinical manifestation, treatments and prognosis of patients with neuropsychiatric systemic lupus erythematosus （NPSLE） . Methods： Clinical manifestation, imaging data, laboratory indexes, treatments and prognosis were analyzed retrospectively in 34 patients diagnosed as NPSLE. Results： Among 818 cases with SLE, 34 cases were diagnosed with NPSLE （4.16%）. The most frequent initial manifestations were headache （24.2%） and cerebrovascular symptoms and signs （22.3%） ; fever （97.1%） and newly emerging rash （61.8%） were the most common accompanied general symptoms. According to SLEDAI score, 76.5% of NPSLE patients were in severe active stage （SLEDAI score ≥ 15 ）. Conclusion： The symptoms of NPSLE were heterogeneous. It was common that NPSLE present two or more clinical subtypes at the same time. Cerebral imaging examination was important for the diagnosis of NPSLE.

关 键 词：系统性红斑狼疮 神经精神狼疮 临床分型 临床表现 治疗 

分 类 号：R593.24[医药卫生—内科学]