西洋参多糖对BABL／C小鼠肝癌肿瘤的抑制效果  

Immunosuppressive effect of a Glucogalactan from Panax quinquefolium L. on hepatocellular carcinoma model of BABL/C mice

作　　者：朱文静[1] 杨秀华[1] 郭存丽[1] 安婷婷[1] 张久维[1] 

机构地区：[1]哈尔滨医科大学附属第一医院超声科,哈尔滨150001

出　　处：《实用肿瘤学杂志》2012年第6期486-489,共4页Practical Oncology Journal

基　　金：国家自然科学基金项目（81171346）;黑龙江省教育厅科学技术研究面上项目（12511327）

摘　　要：目的研究西洋参根中多糖对肝脏恶性肿瘤的抑制作用，探索西洋参多糖对肝脏肿瘤的治疗作用。方法我们建立了BABL／C小鼠肝癌模型，用多糖干扰小鼠肝癌的发生发展，观测小鼠肝脏肿瘤以及脾脏的变化，评估小鼠的抗肝癌效果和西洋参多糖的免疫调节效果。结果随着多糖用量的加大，小鼠肿瘤重量明显减小，肿瘤抑制率明显增加（P〈0．05），小鼠免疫调节越显著。结论可见西洋参多糖对肿瘤的抑制作用明显，可以为肿瘤免疫治疗提供一条新途径。Objective For the research suppression glucogalactan from the roots of Panax quinquefolium to hepatocellular carcinoma, we study the treatment effect of glucogalactan from Panax Quinquefolium （PPQ）to hepatocellular carcinoma. Methods We established BABL/C mouse model of hepatocellular carcinoma; used PPQ interference mouse hepatocellular carcinoma development;observed the variation of mouse hepatocellular car- cinoma and spleen and estimated effect of anti - hepatocellular carcinoma and PPQ immunoregulation. Results With the increasing of PPQ dosage, mice tumor weight decrease obviously, and tumor inhibitory rate increase obvi-ously（P 〈 0. 05 ）. Mice immunoregulatory effect is remarkable. Conclusion So, PPQ to the tumor inhibition is obvious. It may provide a new way for tumor immunotherapy.

关 键 词：西洋参 肝细胞癌 H22癌细胞 免疫调节 

分 类 号：R735.7[医药卫生—肿瘤]