双侧大容量全肺灌洗治疗肺泡蛋白沉着症一例报道并文献复习  

Treatment of pulmonary alveolar proteinosis with bilateral whole lung lavage： a case report and literature review

作　　者：卞京文[1] 陆康生[2] 顾学文[3] 朱慕云[1] 李梅[1] 

机构地区：[1]江苏省苏北人民医院呼吸科,江苏扬州225001 [2]江苏省苏北人民医院麻醉科,江苏扬州225001 [3]江苏省苏北人民医院病理科,江苏扬州225001

出　　处：《临床内科杂志》2012年第12期827-829,共3页Journal of Clinical Internal Medicine

摘　　要：目的通过病例报道及文献复习，提高临床医生对肺泡蛋白沉着症的认识。方法回顾分析1例双侧大容量全肺灌洗治疗肺泡蛋白沉着症患者的临床资料及国内外相关文献。结果活动后气急和咳嗽是肺泡蛋白沉着症的主要症状，体征较少，肺部影像学表现多样化，肺功能主要表现为限制性通气功能障碍和弥散功能障碍，确诊需病理检查。全肺灌洗为治疗肺泡蛋白沉着症的标准方案。结论肺泡蛋白沉着症为一罕见疾病，易误诊及漏诊，加强对该病的认识是提高诊断的关键。Objective To improve the doctors＇ awareness of pulmonary alveolar proteinosis （PAP） through case report and literature review. Methods To retrospectively analyze the clinical fea- tures of a case about bilateral whole lung lavage in PAP and review relative literatures both at home and a- broad. Results The main symptoms of PAP were breath lessness after activity and cough with few physi- cal signs, pulmonary imaging features were varied, and pulmonary function mainly presented with restric- tive ventilation dysfunction and diffusion dysfunction. Pathological examination confirmed the diagnosis and the standard therapy was whole lung lavage. Conclusion The incidence of PAP is rare ,with severe ima- ging features but few manifestations. It remains to be easily misdiagnosed, and awareness of this disease is the key to improve diagnosis rate.

关 键 词：肺泡蛋白沉着症 全肺灌洗 

分 类 号：R563[医药卫生—呼吸系统]