单核钴配合物的合成、结构及其与DNA、BSA作用的研究  

Synthesis,Crystal Structure,DNA Binding and Interaction with Bovine Serum Albumin of Mononuclear Cobalt(Ⅲ) Complex

作　　者：卢静[1] 孙倩[1] 田金磊[1] 顾文[1] 刘欣[1] 阎世平[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《南开大学学报（自然科学版）》2012年第5期92-98,共7页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：国家自然科学基金(21171101;21001066)

摘　　要：合成了1个新的单核钴配合物[CoL_2](ClO_4)_3·CH_3CH_2OH(L=8-(2-甲基吡啶)-氨基喹啉),通过红外光谱和元素分析对配合物进行了初步表征.X-射线单晶结构分析表明,2个三齿配体L与中心三价钴离子参与配位.采用电子吸收光谱、荧光光谱等方法研究了配合物与CT-DNA和BSA的相互作用,结果表明,配合物通过插入方式与CT-DNA键合,配合物与BSA的作用为静态淬灭过程.A new cobalt （III） complex [CoL2] （ClO4）3（CH3CH2OH） （L is 8 [（pyridyl methyl） amino] quinoline） has been synthesized and characterized by infrared spectroscopic analysis and elementary analysis. Single crystal structure of the complex exhibit that it is a mononuclear complex and each neutral ligand L acts as a tridentate terrninal ligand to coordinate cobalt center. The interaction of the compounds with calf thymus DNA （CT-DNA） has been explored by absorption and emission titration methods, which revealed that the complex could interact with CT-DNA through intercalation. The interaction of the complex with bovine serum albumin （BSA） was also investigated by UV-visible and fluorescence methods. The result suggests that the complex could quench the intrinsic fluorescence of BSA in a static quenching process.

关 键 词：钴(Ⅲ)配合物 晶体结构 插入键合 BSA 静态淬灭 

分 类 号：O614.812[理学—无机化学]