正交试验优选白及多糖柔性脂质体制备工艺  

Optimization of Preparation Procedure for Flexible Nanoliposomes of Rhizoma Bletillae Polysaccharide by Orthogonal Test

作　　者：余学英[1] 王刚[1] 常明泉[1] 杜士明[1] 杨光义[1] 叶方[1] 

机构地区：[1]湖北医药学院附属太和医院药学部,湖北十堰442000

出　　处：《中国药师》2012年第11期1620-1623,共4页China Pharmacist

基　　金：湖北省教育厅基金(编号:B20122418)

摘　　要：目的:研究以大豆卵磷脂与胆固醇、胆酸钠、维生素E作为透皮给药系统,制备白及多糖柔性脂质体的制备工艺。方法:采用正交试验法,以柔性脂质体包封率和载药量等作为评价指标,采用多指标综合分析方法优选白及多糖柔性脂质体的最佳比例。结果:白及多糖柔性脂质体的最佳制备工艺为:大豆卵磷脂与胆固醇比例(1.5:1),胆酸钠的加入量(质量比1.0%),探头超声时间5 min,以此制备工艺制得的白及多糖柔性脂质体包封率和载药量较为理想。结论:以优选工艺制备柔性脂质体可提高白及多糖的包封率高和载药量。Objective：To optimize the preparation technology of Rhizoma Bletillae polysaccharide-loaded flexible nanoliposomes consisting of soy lecithin,cholesterol,sodium cholate and vitamin E.Method：The drug loading and encapsulation elliciency as the evaluation indices,a multi-index comprehensive analysis was applied to optimize the proportion of the flexible nanoliposomes by orthogonal test.Result;The optimum proportion and composition of the flexible nanoliposomes were as follows：the rale of soy lecithin and choleslerol oil was 1.5- 1.and the amount of sodium cholate was 1.0%and the ultrasonic time was 5 min.liolh tlie entrapment efficiency and drug loading of the obtained nanoliposomes were promising.Conclusion：The enlrapmenl efficiency and drug loading of Rliizonia Blelillae polysaccharide-loaded flexible nanoliposomes can be improved using the optimized preparation technology.

关 键 词：白及多糖 柔性脂质体 制备工艺 正交试验 

分 类 号：R944.9[医药卫生—药剂学]