姜黄素固体分散体抗肿瘤的药理学研究  

Pharmacological Researches of Curcumin Solid Dispersions in Treatment of Cancer

作　　者：梅雪婷[1] 许东晖[1] 何雪妮 陆永昌 

机构地区：[1]中山大学生命科学学院中药与海洋药物实验室,广东广州510275 [2]广东中大绿原生物科技有限公司,广东广州510275

出　　处：《中药材》2012年第10期1645-1649,共5页Journal of Chinese Medicinal Materials

摘　　要：目的:评价姜黄素固体分散体抗肿瘤的药理学作用。方法:采用专利技术制备姜黄素固体分散体,开展姜黄素固体分散体对多种肿瘤细胞SCG-7901、BEL-7402、S-180、艾氏腹水瘤进行细胞学及整体动物学抗肿瘤评价,以及与抗肿瘤药物顺铂联合使用的药效评价。结果:实验证明姜黄素固体分散体对多种肿瘤具有明显的抗肿瘤效果,与顺铂联合使用具有提高抗肿瘤疗效的作用。结论:姜黄素固体分散体对多种肿瘤具有明显的抗肿瘤效果,同时能够提高顺铂抗肿瘤药物的疗效,可作为肿瘤患者的辅助用药。Objective：To investigate the anticancer effect of curcumin Solid Dispersions（SDs）.Methods：Curcumin SDs were prepared by patent technology.The anticancer effect of curcumin SDs were investigated by vivo and vitro tests of SCG-7901,BEL-7402,S-180 and Ehrlich ascites tumor models.Results：The results showed that Curcumin SDs had markedly anticancer effect and could improve the anticancer effect of cisplatin.Conclusion：Curcumin SDs could be developed into one kind of adjuvant drug for anticancer,as it has markedly anticancer effect,and could improve the anticancer effects of cisplatin.

关 键 词：姜黄素 固体分散体 抗肿瘤 顺铂 辅助用药 

分 类 号：R285.5[医药卫生—中药学]