Analysis of Gene Networks for Arabidopsis Flowering  

作　　者：Yansen Su Dazhi Meng Eryan Li Shudong Wang 

机构地区：[1]Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China [2]College of Applied Sciences, Beijing University of Technology, Beijing 100124, China [3]Institute of Information Science and Engineering, Shandong University of Science and Technology, Qingdao 266510, China

出　　处：《Tsinghua Science and Technology》2012年第6期682-690,共9页清华大学学报（自然科学版（英文版）

基　　金：Supported by the National Natural Science Foundation of China (Nos.61170183,61033003, and 91130034);the Foundation for the Excellent Middle-Aged and Youth Scientists of Shandong Province of China(No.BS2011SW025)

摘　　要：The flowering time of Arabidopsis is sensitive to climate variability, with lighting conditions being a major determinant of the flowering time. Long-days induce early flowering, while short-days induce late flowering or even no flowers. This study investigates the intrinsic mechanisms for Arabidopsis flowering in different lighting conditions using mutual information networks and logic networks. The structure parameters of the mutual information networks show that the average degree and the average core clearly distinguish these networks. A method is then given to find the key structural genes in the mutual information networks and the logic networks respectively. Ten genes are found to possibly promote flowering with three genes that may restrain flowering. The sensitivity of this method to find the genes that promote flowering is 80%, while the sensitivity of the method to find the genes that restrain flowering is 100%.The flowering time of Arabidopsis is sensitive to climate variability, with lighting conditions being a major determinant of the flowering time. Long-days induce early flowering, while short-days induce late flowering or even no flowers. This study investigates the intrinsic mechanisms for Arabidopsis flowering in different lighting conditions using mutual information networks and logic networks. The structure parameters of the mutual information networks show that the average degree and the average core clearly distinguish these networks. A method is then given to find the key structural genes in the mutual information networks and the logic networks respectively. Ten genes are found to possibly promote flowering with three genes that may restrain flowering. The sensitivity of this method to find the genes that promote flowering is 80%, while the sensitivity of the method to find the genes that restrain flowering is 100%.

关 键 词：flowering gene gene network high-order logic mutual information systems biology 

分 类 号：S852.659.2[农业科学—基础兽医学] S682.11[农业科学—兽医学]