Lp—PLA2活性在急性动脉粥样硬化性脑梗死中的临床意义  

Lipoprotein-associated phospholipase A2 （Lp-PLA2）＇ s activity in acute atherosclerosis cerebral infarction

作　　者：陈晓丽[1] 王汉旻[1] 夏君慧[1] 张旭[1] 金得辛[1] 

机构地区：[1]温州医学院附属一医神经内科,浙江325000

出　　处：《中国急救复苏与灾害医学杂志》2012年第12期1104-1107,共4页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的探讨Lp—PLA2活性在急性动脉粥样硬化性脑梗死中临床意义，同时分析其与传统炎性标志物的关系。方法对急性动脉粥样硬化性脑梗死（n=60例）及对照组（n=28例）的所有受试者均检测血浆Lp—PLA2活性和传统危险因素，并进行相互比较；同时分析炎性标志物Lp—PLA2活性与脑梗死临床分型、梗死面积之间关系。结果脑梗死患者血浆Lp—PLA2活性显著高于对照组（P〈0．01），其活性与脑梗死临床分型无关，与梗死面积大小正相关。结论Lp—PLA2活性是急性脑梗死的炎性标志物，Lp—PLA2活性与梗死面积大小正相关，其活性可能与临床转归相关。Objective To explore Lp-PLA2＇s clinical meaning and its relation with the conventional risk factors in cerebral infarction. Methods A comparison was made in between the stroke group of 60 patients with acute atherosclerosis cerebral infarction and the control group of 40 normal people. Activeness of plasma Lp-PLA2, traditional factors were determined, as well as Lp-PLA2, traditional factors with infarct clinical classification, size. Results The followings were found： 1. Lp-PLA2 was inflammatory marker of cerebral infarction, significantly higher than control group （P〈0.01）, and had a positive correlation with infarct size; 2. Lp-PLA2 was an independent risk factor and related with the size of cerebral infarction. Conclusion Lp-PLA2, a novel inflammatory marker, is an risk factor of acute atheroselerosis cerebral infarction. It may serve as an indicator to the prognosis.

关 键 词：脂蛋白相关性磷脂酶A2 动脉粥样硬化 脑梗死 炎症 

分 类 号：R543.1[医药卫生—心血管疾病]