乌药对大鼠急性酒精性肝损伤保护作用的实验研究  

Experimental study on the protect effect of Lindera aggregata （Sims） Kosterm in acute alcoholic liver injury in rats

作　　者：王军伟[1] 陈伟民[1] 朱玮华[1] 

机构地区：[1]浙江天台县人民医院,317200

出　　处：《中国急救复苏与灾害医学杂志》2012年第12期1139-1141,F0003,共4页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的观察乌药对大鼠急性酒精性肝损伤模型肝功能及肝组织的影响。方法将大鼠随机分为5组，正常对照组、模型对照组、阳性对照组、乌药1g·kg-1组、乌药2g·kg-1组。除正常组外，其余各组大鼠均按10mL·kg-1体重灌胃给予经稀释的56度二锅头，每日2次，连续12d，复制大鼠急性酒精性肝损伤模型，治疗组在造模同时给予乌药水提物保护。测定血清天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT），并进行肝脏的病理组织学观察。结果乌药高、低剂量组血清中AST、ALT水平降低，肝组织脂肪变性、坏死、炎症细胞浸润程度减轻。结论乌药水提物对大鼠急性酒精性肝损伤有一定的保护作用。Objective To study the protect effect of Lindera aggregata （Sims） Kosterm in acute alcoholic liver injury in rats. Methods 60 rats were randomly divided into 5 groups, normal control group, model group, positive control group, low-dose treatment group, and high-dose treatment group. The same dosage of alcohol （10mL· kg-1） was given to all four groups except the normal control group for 12 days to make a model of acute alcoholic injury. Simultaneously, a dosage of 1g·kg-1and 2g· kg-1 of Lindera aggregata （Sims） Kosterm was given to the groups except the control group and the model group which were only given water, instead. The blood sample of the rats was obtained to test the levels of aspartate amino transaminase （AST） and alanine amino transaminase （ALT）, and their liver tissue samples were determined pathologically. Results The levels of AST and ALT were significantly increased in model group comparing with that in the normal control group, and decreased in treatment groups than that in model group. The hepatic tissue structure and the cells were much better in the treatment groups than that in model group. Conclusion Lindera aggregata （Sims） Kosterm may carry the protective effects in acute alcoholic liver injury rats.

关 键 词：乌药 急性酒精性肝损伤 

分 类 号：R256.4[医药卫生—中医内科学]