妊娠梅毒患者血清IL-4和IFN-γ水平的检测及意义  被引量:1

Determination of Serum IL-4 and IFN-γin Syphilitic Patients with Pregnancy and Its Clinical Significance

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作  者:袁丽萍[1] 张曙萱[1] 杨晓明[1] 杜雪寒[1] 

机构地区:[1]徐州市第一人民医院妇产科,江苏221006

出  处:《齐齐哈尔医学院学报》2012年第23期3214-3215,共2页Journal of Qiqihar Medical University

基  金:徐州市科技计划项目;项目编号:XM09B111

摘  要:目的探讨白细胞介素4(IL-4)、干扰素-γ(IFN-γ)在妊娠梅毒发病机制中的意义。方法采用双抗体夹心ELISA法检测9例活动期妊娠梅毒患者血清中IL-4和IFN-γ的水平,并以20例正常孕妇作为对照。结果 9例活动期妊娠梅毒患者与正常对照组比较,血清IL-4、IFN-γ水平明显增高(P<0.01)。结论 IL-4和IFN-γ参与了梅毒螺旋体进入体内后的免疫过程,可能在梅毒螺旋体的清除过程中发挥重要的免疫调节作用。Objective To investigate the role of interleukin-4(IL-4) and interferon-gamma(IFN-γ) In the pathogenesis of syphilis with pregnancy. Methods The levels of Serum IL-4 and IFN-γ in 9 patients in active phase of the disease,18 patients in recovery phase of the disease,and 20 healthy pregnancy were measured by ELISA method. Results The levels of Serum IL-4 and IFN-γin 9 patients in active phase of the disease were remarkably higher as compared with those in the control group(P0.01). Conclusions This study showed that IL-4 and IFN-γmay be involved in the control of infection.It may also play a role in the clearance of the TP(Treponema pallidum) from the boby.

关 键 词:梅毒 白细胞介素4 干扰素-Γ 

分 类 号:R512.620.2[医药卫生—内科学]

 

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