辅酶Q10改善冠心病无症状心肌缺血的效果与评价  

Assessment of coenzyme Q10 on silent myocardial ischemia in patients with coronary heart disease

作　　者：陈秋[1] 刘学强[1] 周云[2] 陈一茂[1] 田开新[1] 张雪莲[1] 

机构地区：[1]中国人民解放军第四十二中心医院,四川乐山614100 [2]成都军区天仙桥干休所

出　　处：《社区医学杂志》2012年第24期25-26,共2页Journal Of Community Medicine

摘　　要：目的评价辅酶Q10治疗冠心病无症状性心肌缺血的疗效与安全性。方法随机将84例冠心病无症状心肌缺血患者分为两组,其中治疗组42例,采用辅酶Q10治疗;对照组42例,服用安慰剂。同时两组均服用硝酸异山梨酯、阿司匹林、阿托伐他汀钙片,治疗10周。治疗前后进行24 h动态心电图监测,对比观察缺血及其相关指标。结果治疗10周后,两组治疗后动态心电图ST段压低的次数、持续时间均明显改善,与治疗前比较,差异均有统计学意义(P<0.05)。两组组间比较,治疗组的疗效显著,差异有统计学意义(P<0.05)。治疗期间未见辅酶Q10明显不良反应。结论辅酶Q10治疗冠心病无症状性心肌缺血有效、安全,值得在临床上推广应用。Objective To assess the clinical efficacy and safety of coenzyme Q10（CoQ10） for silent myocardial ischemia （SMI） in patients with coronary heart disease. Methods Eighty - four cases of coronary heart disease with SM1 were ran- domized into two groups： treatment group and control group, 42 cases for each. CoQ10 was given to treatment group and placebo to control group. In addition, both groups were given sorhitrate, aspirin and atorvastatin for ten weeks. The chan- ges of myocardial ischemia were observed by dynamic electrocardiogram before and after treatment. Results After a 10 - week treatment, both groups got improved in the frequency and duration of ST - segment depression, which showed signifi- cant difference （P 〈0.05 ）. There was significant difference between two groups in clinical efflcaey（P 〈0.05）, in which treatment group was superior to control group. No side effects occurred during treatment with CoQ10. Conclusions CoQ10 is safe and effective for SMI in coronary heart disease, which is worthy of clinical application.

关 键 词：辅酶Q10 无症状心肌缺血 冠心病 动态心电图 

分 类 号：R541.4[医药卫生—心血管疾病]