秋水仙碱治疗白塞病25例疗效观察  

Curative effect observation of Colchicine in the treatment of 25 cases of patients with behcet disease

作　　者：尹涛[1] 张玉芳[1] 周琳[1] 钟连生[1] 

机构地区：[1]江苏省徐州医学院附属医院皮肤科,江苏徐州221002

出　　处：《中国医药导报》2012年第34期83-84,共2页China Medical Herald

摘　　要：目的探讨口服秋水仙碱治疗白塞病的疗效及不良反应。方法选择已经确诊无重要脏器损害的白塞病患者25例,给予口服秋水仙碱0.5 mg,每天2次,共8周,观察该药对白塞病患者口腔溃疡、外阴溃疡、结节性红斑、关节疼痛的疗效,并评价其不良反应。结果治疗结束时,口腔溃疡、外阴溃疡、结节性红斑及关节损害的治愈率分别为20.0%、87.5%、80.0%和85.7%;治疗开始时,外阴溃疡、结节性红斑及关节损害的平均数量分别为(4.80±3.24)、(7.31±3.44)、(6.60±3.24)、(3.57±1.81)个,治疗8周后分别为(3.84±3.54)、(1.41±0.50)、(2.42±1.10)、(1.89±0.71)个,外阴溃疡、结节性红斑及关节损害的平均数量在治疗8周后均显著低于治疗前(P<0.01)。常见不良反应包括恶心、腹痛及腹泻等消化道症状,未见其他严重不良反应。结论秋水仙碱可以作为白塞病患者的一线治疗药物。Objective To investigate the effect and adverse reactions of Colchicine in the treatment of behcet disease.Methods 25 cases of patients confirmed with behcet disease without important organ damage were selected to take Colchicine 0.5 mg orally twice a day for eight weeks,and the curative effect of Colchicine on oral ulcer,vulva ulcer,ery thema nodosum and arthralgia were observed,its adverse reactions were evaluated also.Results At the end of the treatment,the cure rate of oral ulcer,vulva ulcer,erythema nodosum and arthralgia were 20.0%,87.5%,80.0% and 85.7%.At the beginning of treatment,the average amount of vulva ulcer,erythema nodosum and arthralgia were（4.80±3.24）,（7.31± 3.44）,（6.60±3.24） and（3.57±1.81）.8 weeks after treatment,they were（3.84±3.54）,（1.41±0.50）,（2.42±1.10） and（1.89± 0.71） respectively.And they were significantly lower than before treatment（P0.01）.The common adverse reactions were gastrointestinal symptoms,such as nausea,abdominal pain and diarrhea,etc.There were no other serious adverse reactions.Conclusion Colchicine can be used as a first-line regimen for behcet disease patients.

关 键 词：白塞病 秋水仙碱 疗效 

分 类 号：R282.710.7[医药卫生—中药学]