坦索罗辛联合索利那新治疗良性前列腺增生伴膀胱过度活动症  

Combination of tamsulosin and solifenacin treatment for benign prostatic hyperplasia with overactive bladder

作　　者：何晓英[1] 张永革[2] 杨茜[1] 

机构地区：[1]兰州军区兰州总医院药剂科,兰州730050 [2]解放军第一医院泌尿外科,兰州730030

出　　处：《实用药物与临床》2012年第12期806-807,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的评价坦索罗辛联合索利那新治疗良性前列腺增生伴膀胱活动过度症的疗效。方法选择经临床确诊的良性前列腺增生伴膀胱过度活动患者85例,随机分成单药组和联合组,单药组45例,单用坦索罗辛(0.2 mg,口服,1次/晚);联合组40例,服用坦索罗辛(0.2 mg,口服,1次/晚)和索利那新(5 mg,1次/d)。两组分别在治疗前和治疗12周后行国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)及膀胱过度活动症状评分(OABSS)测定,并对出现的不良反应进行记录。结果治疗后,单药组IPSS、QOL评分及Qmax均有改善(P<0.05),OABSS无明显改善;联合组IPSS、QOL评分、Qmax及OABSS均有明显改善(P<0.05),且联合组IPSS、QOL评分、OABSS改善情况明显优于单药组。结论坦索罗辛联合索利那新不仅可以改善BPH所导致的梗阻症状,还可以更好地减轻患者的膀胱过度活动症状,改善患者的生活质量。Objective To evaluate the efficacy of tamsulosin combined with solifenacin on BPH with overactive bladder.Methods 85 BPH patients with overactive bladder were randomly divided into single group（n=45）and combination group（n=40）.The single group was treated with 0.2 mg tamsulosin once daily for 12 weeks,and the combination group was treated with 0.2 mg tamsulosin and 5 mg solifenacin once daily for 12 weeks.Before and after the treatment,we recorded the International Prostate Symptoms Score（IPSS）,quality of life score（QOL）,Overactive Bladder Symptoms Score（OABSS）,Qmax,and the adverse events.Results In the single group,the IPSS,QOL,Qmax was improved（P0.05）.In the combination group,the improvement of IPSS,QOL and OABSS were more significant than those of single group（P0.05）.Conclusion The combined use of tamsulosin and solifenacin could not only relieve obstructive symptoms,but also relieve overactive bladder symptoms of BPH patients.

关 键 词：坦索罗辛 索利那新 良性前列腺增生 膀胱过度活动 下尿路症状 

分 类 号：R697.3[医药卫生—泌尿科学]