苯佐卡因的合成  

Synthesis of Benzocaine

作　　者：于丽颖[1] 

机构地区：[1]吉林化工学院化学与制药工程学院,吉林吉林132022

出　　处：《广州化工》2012年第24期112-113,共2页GuangZhou Chemical Industry

摘　　要：主要研究了以对甲基苯胺为原料通过酰胺化、氧化、水解和酯化合成苯佐卡因的合成工艺条件条件。实验结果表明,对甲基苯胺酰胺化反应收率可达96.4%,氧化反应收率可达96.5%,酯化反应收率为75.2%,苯佐卡因的总收率可达50%左右。实验中酰胺化氧化产物水解对酯化反应影响较大,实验中采用正交实验法对水解反应进行研究,并对实验结果和数据进行分析。通过红外光谱和熔点测定对目标化合物苯佐卡因进行了结构表征。Benzocaine was synthesized through the amidation,oxidation,hydrolysis,and esterification based on p-methyl-aniline.The results revealed that the total yield of benzocaine can reach 50%,including 96.4%amidation of p-methyl-aniline,96.5% oxidation,and 75.2% esterification.In the experiment,the product hydrolysis of amidation and oxidation had an effect on esterification.The hydrolysis reaction was studied through orthogonal experiment,and the result and data of the experiment were analyzed.The structure of benzocaine was determined through melting point detecting and IR spectra.

关 键 词：对甲基苯胺 苯佐卡因 合成 

分 类 号：TQ463[化学工程—制药化工]