左旋甲状腺素对亚临床甲减、临床甲减患者疗效的影响  

Effect influence of Levothyroxine to the patients with subclinical hypothyroidism and clinical hypothyroidism

作　　者：黄枝优[1] 

机构地区：[1]广西壮族自治区百色市人民医院,广西百色533000

出　　处：《中国当代医药》2012年第34期55-56,共2页China Modern Medicine

摘　　要：目的探讨左旋甲状腺素对亚临床甲减、临床甲减患者的疗效。方法回顾性分析2010年2月～2012年2月本院门诊收治的128例甲状腺功能减退症患者的临床资料,临床甲减组46例,亚临床甲减组82例。均给予口服左旋甲状腺素钠治疗。观察比较两组血脂水平。结果亚临床甲减组治疗前TSH水平较临床甲减组低(P<0.05),FT4水平较临床甲减组高(P<0.05);两组治疗后TC、TG、LDL水平均较治疗前明显下降(P<0.05),HDL下降不明显,差异无统计学意义(P>0.05)。临床甲减组治疗后TC下降幅度较亚临床甲减组显著(P<0.05)。结论应用左旋甲状腺素治疗亚临床甲减、临床甲减患者能够缓解临床症状,改善血脂。Objective To investigate the effect of Levothyroxine to the patients with subclinical hypothyroidism and clinical hypothyroidism. Methods Clinical data of 128 cases of patients with hypothyroidism in outpatients of our hospital from February 2010 to February 2012 were retrospectively analyzed, clinical hypothyroidism group had 46 cases, subclinical hypothyroidism group had 82 cases. They were all given oral levothyroxine sodium therapy. Blood lipid level in two groups were observed and compared. Results Level of TSH Subclinical before treatment in subclinical hypothyroidism group was lower than that in clinical hypothyroidism （P0.05）, level of FT4 was higher than that in clinical hypothyroidism （P0.05）; Levels of TC, TG, LDL after treatment in two groups were significantly decreased （P0.05）, HDL decreased without significantly, the difference was not statistically significant （P0.05）. TC in clinical hypothyroidism group after treatment dropped more than subclinical hypothyroidism group （P 0.05）. Conclusion The application of Levothyroxine to the patients with subclinical hypothyroidism and clinical hypothyroidism can relieve clinical symptoms and improve the blood lipids.

关 键 词：左旋甲状腺素 亚临床甲减 临床甲减 血脂水平 

分 类 号：R582.2[医药卫生—内分泌]