沙美特罗替卡松治疗感染后咳嗽的疗效分析  

Analysis of Curative Effect of Salmeterol and Fluticasone Propionate for Post-infectious Persistent Cough

作　　者：蒋蕊[1] 魏东光[1] 

机构地区：[1]山西省人民医院,山西太原030012

出　　处：《山西职工医学院学报》2012年第6期27-29,共3页Journal of Shanxi Medical College for Continuing Education

摘　　要：目的:探讨使用沙美特罗替卡松粉吸入剂治疗感染后咳嗽的临床疗效。方法:采用前瞻性随机对照研究方法,将感染后咳嗽患者85例随机分为2组。A组患者给予吸入沙美特罗替卡松粉(50μg沙美特罗和250μg丙酸氟替卡松),1吸/次,2次/d,疗程7 d;B组患者给予口服酮替芬片1 mg,2次/d,疗程7 d。通过咳嗽积分及视觉模拟评分体系对患者的咳嗽严重程度进行量化评估。结果:沙美特罗替卡松粉治疗感染后咳嗽疗效优于酮替芬的治疗,差异有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论:沙美特罗替卡松粉吸入剂(50μg沙美特罗和250μg丙酸氟替卡松)治疗感染后咳嗽疗效好,安全性高,值得临床推广。Objective： To investigate the treatment with salmeterol and fluticasone propionate in patients with post-infectious persistent cough.Methods： By a prospective randomized controlled method,a total of eighty-five patients with post-infectious persistent cough were divided into two groups.The patients in group A were treated with salmeterol and fluticasone propionate（salmeterol and fluticasone 50 μg,propionate 250 μg）,1 suction per/time,twice a day and the patients in group B were treated with ketotifen 1 mg twice a day with a 10-day treatment term.The efficacy was measured both by cough score and visual imitation scoring system（VAS）.Results： The treatment with salmeterol and fluticasone propionate（group A） resulted in a greater reduction of cough frequency in patients with post-infectious persistent cough in comparison to the treatment with ketotifen（group B）.There were statistically significant differences between the two groups（P〈0.05）.Few and mild side effects were observed in the two groups and had no statistically significant difference.Conclusion： Salmeterol and fluticasone propionate salmeterol and fluticasone 50 μg and propionate 250 μg,can be recommended as an effective and well-tolerated therapeutic option in the treatment of post-infectious persistent cough.

关 键 词：沙美特罗替卡松粉 酮替芬片 感染后咳嗽 

分 类 号：R56[医药卫生—呼吸系统]