S100B在慢性心力衰竭诊疗中的临床意义  

Clinical application of S100B protein to diagnosis and therapy of chronic heart failure

作　　者：任妍[1] 虞莹珺[1] 李金平[1] 苏倩[1] 周清芬[1] 张凤如[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院老年科,200025

出　　处：《国际心血管病杂志》2012年第6期385-388,共4页International Journal of Cardiovascular Disease

摘　　要：目的:探讨慢性心力衰竭(CHF)患者血清S100B蛋白水平与心功能及CHF病因的关系。方法:将234例CHF患者按病因分为扩张型心肌病组(n=133)和缺血性心肌病组(n=101),并以117名正常人作为对照组。测定血清S100B、N-末端B型利钠肽原(NT-proBNP)和高敏C反应蛋白(hsCRP)水平。结果:CHF患者S100B水平明显升高,血清S100B水平与左室射血分数(LVEF)及NT-proBNP呈相关性。S100B蛋白水平较高的患者发生主要心血管终点事件风险较高,但在缺血性心肌病组与扩张型心肌病组中蛋白水平无明显差异。结论:S100B蛋白水平在慢性心力衰竭患者中明显升高,且与患者心功能呈负相关,是慢性心力衰竭发生发展的独立危险因素,对于慢性心力衰竭患者的预后转归有提示意义。Objective： To investigate the serum levels of S100B protein in patients with chronic heart failure, and to analyze the association of S100B protein with cardiac function and etiology of heart failure. Methods：A total of 234 patients were enrolled in this study, divided into two groups according to the pathogens, dilated cardiomyopathy group （n = 133） and ischemic cardiomyopathy group （n = 101）. The control group consisted of 117 healthy individuals （n = 117）. Serum levels of S100B , N - terminal pro-brain natriuretic peptide （ NT -proBNP ） and high sensitivity C reactive protein （hsCRP） were determined in all subjects. Results： Serum levels of S100B were higher in patients with chronic heart failure, and were positively correlated with NT-proBNP and negatively correlated with LVEF. Increased S100B levels were associated with major cardiac events, but the differences of S100B levels in patients with CHF caused by dilated cardiomyopathy and ischemic cardiomyopathy were not remarkable. Conclusion： S100B protein is highly expressed in patients with chronic heart failure, and its serium level is negatively correlated with cardiac function, suggesting S100B protein may be an independent risk factor for chronic heart failure.

关 键 词：慢性心力衰竭 SIOOB 预后转归 

分 类 号：R541.6[医药卫生—心血管疾病]