脉搏波速度与冠状动脉病变的相关性研究  

Relationship between pulse wave velocity and severity of coronary artery disease

作　　者：倪琦[1] 许建忠[2] 王长谦[2] 蒋金全[1] 

机构地区：[1]上海市第二人民医院心内科,200011 [2]上海交通大学医学院附属第九人民医院心内科,200011

出　　处：《国际心血管病杂志》2012年第6期392-394,共3页International Journal of Cardiovascular Disease

摘　　要：目的:应用脉搏波速度(pulse wave velocity,PWV)评价血管僵硬度,观察PWV与冠心病危险因素的相关性,及其对冠状动脉病变严重程度的预测价值。方法:入选132例因胸痛疑诊冠心病而行冠脉造影的患者,其中男性68例,女性64例,平均年龄(66.4±10.0)岁。根据冠脉造影的结果,将患者分为冠状动脉正常组(Ⅰ组,n=32),冠状动脉病变单支组(Ⅱ组,n=33)、2支组(Ⅲ组,n=27)和3支组(Ⅳ组,n=40);同时有创测量中心动脉收缩压(CSBP)、舒张压(CDBP)及脉压(CPP)。用欧姆龙动脉硬化检测仪测量患者臂踝PWV(baPWV)。检测体质指数、血脂、颈总动脉内膜中层厚度、血清肌酐、左室质量指数等冠心病危险因素。结果:逐步多变量回归分析显示,年龄(β=0.46,P<0.01)和CSBP(β=0.19,P=0.013)与baPWV明显相关。baPWV比较:Ⅰ组与Ⅱ组无统计学差异(P=0.83);Ⅲ组、Ⅳ组较Ⅰ组和Ⅱ组明显升高(P<0.05);Ⅲ组与Ⅳ组无统计学差异(P=0.47)。结论:年龄和CSBP是影响baPWV的两个独立危险因素。baPWV与冠状动脉病变严重程度明显相关,可以作为无创、简便、可重复的预测冠状动脉病变程度的一个重要指标。Objective：To evaluate the correlation of pulse wave velocity （PWV） with severity of coronary artery disease （CAD）. Methods ：132 patients were divided into four groups： Non-CAD（Group I ,n = 32）, one-vessel disease （Group II ,n = 33）, two-vessel disease （Group III ,n = 27）, three-vessel disease groups （Group IV ,n = 40） based on angiography. BaPWV was assessed. Central arterial blood pressure, intima-media thickness （IMT） of common carotid, and left ventricular mass index （LVMI） were investigated. Results： BaPWV was higher in three-vessel disease groups, two-vessel disease group, compared to those with non CAD group. There were no differences between non CAD and one- vessel disease group. In stepwise multivariate regression analysis, baPWV correlated with age （β = 0. 46 , P〈0. 01） and central SBP （β = 0. 19,P = 0. 013 ）. Conclusion：This study suggested that age and central SBP could be regarded as independent risk factors impairing baPWV. BaPWV may be an important factor leading to CAD, which might be considered as a marker for evaluating the severity of CAD.

关 键 词：臂踝脉搏波速度 冠心病 中心动脉压 

分 类 号：R541.4[医药卫生—心血管疾病]