孕激素受体发挥作用的机制及其调控因素  

The Mechanism and Regulation Factors of Progesterone Receptor Activation

作　　者：刘颖[1] 谢梅青[1] 

机构地区：[1]中山大学孙逸仙纪念医院妇产科,广州510120

出　　处：《国际妇产科学杂志》2012年第6期570-573,共4页Journal of International Obstetrics and Gynecology

摘　　要：孕激素受体对介导孕激素在组织中的生物学作用有重要作用,其是核转录调节因子,主要有2种亚型。在胞核内孕激素受体可调节靶基因的转录,在胞质中还能激活相关信号通路,共同调节细胞的增殖和分化。孕激素受体功能的发挥受多种因素调节,包括协同调节因子、蛋白质翻译后修饰、受体基因转录水平等,各种调控因素的变化都会影响孕激素受体功能的正常发挥,致使其对靶器官的调控失常。The biological action of progesterone mediates by progesterone receptor（PR） which is expressed as two isoforms,PRA and PRB.PR is a member of ligand-activated nuclear transcription regulators,and it also can active signaling pathways extra-nuclear.PR plays an important role in cell proliferation and differentiation.There are many factors regulating the activation of progesterone receptor,such as synergic regulators,post-translational modifications and gene transcription.The disorder of PR activations may lead to pathologic changes of target organs.

关 键 词：受体 孕酮 基因表达调控 蛋白质生物合成 信号传导 转录 遗传 

分 类 号：R96[医药卫生—药理学]