随机尿白蛋白/肌酐与24h尿微量白蛋白相关性研究  

Correlation between the random urine albumin/creatinine and 24 h-mAlb

作　　者：张学锋[1] 朱立荣[1] 刘建广[1] 徐璟[1] 刘德敏[1] 

机构地区：[1]天津医科大学代谢病医院检验科卫生部激素与发育重点实验室,天津300070

出　　处：《天津医科大学学报》2012年第4期467-468,共2页Journal of Tianjin Medical University

摘　　要：目的:观察糖尿病患者24 h尿微量白蛋白(24 h-mAlb)与随机尿白蛋白/肌酐比值(ACR)和晨尿ACR的相关性,探讨采用随机尿ACR代替24 h-mAlb用于糖尿病早期肾损伤筛查的可行性。方法:收集120位住院患者24 h尿、晨尿、随机尿的尿液标本,用透射免疫比浊法测定24 h-mAlb,用散射免疫比浊法测定ACR。结果:晨尿组ACR与随机尿组ACR无统计学差异(P>0.05),晨尿组ACR与24 h-mAlb呈正相关(r=0.714 5,P<0.01),相关性良好;随机尿组ACR与24 h-mAlb呈正相关(r=0.823 5,P<0.01),相关性良好。结论:测定随机尿ACR方法简单易行,尤其是方便门诊病人,可代替24 h-mAlb用于糖尿病早期肾损伤筛查。Objective： To examine the feasibility of using random urine ACR instead of 24 h urinary albumin（24 h-mAlb） for early renal injury screening by observing the correlation between the 24 h-mAlb and random urine ACR and the morning urine ACR of diabetic pa- tients. Methods： The 24 h urine, morning urine, random urine fluid samples from 120 hospitalized patients were collected, then the 24 h-mAlb was measured by transmission immune turbidimetric method, and the ACR was measured by scattering immune turbidimetric method. Results： There was no significant difference in ACR compared morning urine group with random urine group （P〉0.05）; It showed a positive correlation between the morning urine group and 24h-mAlb （r=0.714 5, P〈0.01）; The ACR of random urine group was positive- ly correlated with 24 h-mAlb （r=0.823 5, P〈0.01）. Conclusion： The random urine ACR could instead of 24 h-mAlb for early renal injury screening, which is worth developing for it is simple, convenient for patients, especially outpatients.

关 键 词：白蛋白 肌酐比值 晨尿 随机尿 微量白蛋白 糖尿病早期肾损伤 

分 类 号：R446[医药卫生—诊断学] R587.1[医药卫生—临床医学]