Tumour length is an independent prognostic factor of esophageal squamous cell carcinomas  

作　　者：WU Ning PANG Lie-wen CHEN Zhi-ming MA Qin-yun CHEN Gang 

机构地区：[1]Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China

出　　处：《Chinese Medical Journal》2012年第24期4445-4448,共4页中华医学杂志（英文版）

摘　　要：Background The latest version of the American Joint Committee on Cancer （AJCC） TNM staging system has not comprehensively evaluated the impact of tumour length on survival in patients with esophageal squamous cell carcinoma. Our study explored the relationship between tumour length and clinicopathological characteristics as well as long-term survival. Methods All 202 cases of esophageal resections done from January 1, 2004 to December 31, 2008 in Huashan Hospital, Fudan University were reviewed and followed up. Results Patients with tumour length 〉3 cm were related to more advanced tumour stage （χ2=55.9, P 〈0.001）, more metastatic lymph nodes （χ2=14.6, P 〈0.001）, increased metastatic lymph node ratio （χ2=16.1, P 〈0.001） and worse overall TNM stage （χ2=48.1, P 〈0.001）. Univariate and multivariate analyses indicated that tumour length was a significant prognostic risk factor （95% CI 0.235-0.947, P=-0.035）. Subgroup analyses disclosed that tumour length was a valuable prognostic predictor in patients with lower T stage, absence of metastatic lymph nodes and lower TNM stage. Conclusions Esophageal tumour length is a predictive factor for long-term survival especially for lower tumour stage, absence of metastatic lymph nodes and lower TNM stage patients. Tumour length should be incorporated in the staging system as an important grouping factor for better prognostic evaluation.Background The latest version of the American Joint Committee on Cancer （AJCC） TNM staging system has not comprehensively evaluated the impact of tumour length on survival in patients with esophageal squamous cell carcinoma. Our study explored the relationship between tumour length and clinicopathological characteristics as well as long-term survival. Methods All 202 cases of esophageal resections done from January 1, 2004 to December 31, 2008 in Huashan Hospital, Fudan University were reviewed and followed up. Results Patients with tumour length 〉3 cm were related to more advanced tumour stage （χ2=55.9, P 〈0.001）, more metastatic lymph nodes （χ2=14.6, P 〈0.001）, increased metastatic lymph node ratio （χ2=16.1, P 〈0.001） and worse overall TNM stage （χ2=48.1, P 〈0.001）. Univariate and multivariate analyses indicated that tumour length was a significant prognostic risk factor （95% CI 0.235-0.947, P=-0.035）. Subgroup analyses disclosed that tumour length was a valuable prognostic predictor in patients with lower T stage, absence of metastatic lymph nodes and lower TNM stage. Conclusions Esophageal tumour length is a predictive factor for long-term survival especially for lower tumour stage, absence of metastatic lymph nodes and lower TNM stage patients. Tumour length should be incorporated in the staging system as an important grouping factor for better prognostic evaluation.

关 键 词：esophageal squamous cell carcinoma tumour length PROGNOSIS 

分 类 号：S858[农业科学—临床兽医学] TH774[农业科学—兽医学]