Study of cochlear hydrops analysis masking procedure in patients with Meniere＇s disease and otologically normal adults  

作　　者：SHANG Ying-ying DIAO Wen-wen NI Dao-feng GAO Zhi-qiang XU Chun-xiao LI Feng-rong 

机构地区：[1]Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

出　　处：《Chinese Medical Journal》2012年第24期4449-4453,共5页中华医学杂志（英文版）

摘　　要：Background The cochlear hydrops analysis masking procedure （CHAMP） is a new diagnostic technique for Meniere＇s disease （MD）. But its value has not been well proven. This study aimed to evaluate the diagnostic value of CHAMP for MD. Methods CHAMP test was taken in three populations using the Auditory Evoked Potential system delivered by Bio-logic Systems Corporation： （1） otologically normal subjects; （2） patients clinically diagnosed with definite MD; （3） patients clinically diagnosed with probable and possible MD. Results According to the comparison between the normal and definite MD group, if the abnormal criterion of CHAMP was defined as latency delay less than 0.3 ms, then the corresponding sensitivity was only 52%. However, if the abnormal criterion was defined as latency delay between 0.6 and 3.8 ms, then a sensitivity of 93% and a specificity of 100% can be achieved. The complex amplitude ratio showed a significant overlap between normal and definite MD group. If the abnormal criterion was defined as a complex amplitude ratio less than 0.95, the corresponding specificity was only 50%. However, if the abnormal cdtedon was defined as less than 0.80, the corresponding sensitivity was 60%, and the specificity was 97%. If the abnormal criterion of CHAMP was defined as latency delay less than 0.6 ms or the complex amplitude ratio less than 0.80, CHAMP result can be obtained in all subjects with good sensitivity and specificity. Conclusions CHAMP can differentiate patients with Meniere＇s disease from otologically normal subjects with high sensitivity and specificity. The recommended cdterion of abnormal CHAMP was a latency delay less than 0.6 ms or a complex amplitude ratio less than 0.80.Background The cochlear hydrops analysis masking procedure （CHAMP） is a new diagnostic technique for Meniere＇s disease （MD）. But its value has not been well proven. This study aimed to evaluate the diagnostic value of CHAMP for MD. Methods CHAMP test was taken in three populations using the Auditory Evoked Potential system delivered by Bio-logic Systems Corporation： （1） otologically normal subjects; （2） patients clinically diagnosed with definite MD; （3） patients clinically diagnosed with probable and possible MD. Results According to the comparison between the normal and definite MD group, if the abnormal criterion of CHAMP was defined as latency delay less than 0.3 ms, then the corresponding sensitivity was only 52%. However, if the abnormal criterion was defined as latency delay between 0.6 and 3.8 ms, then a sensitivity of 93% and a specificity of 100% can be achieved. The complex amplitude ratio showed a significant overlap between normal and definite MD group. If the abnormal criterion was defined as a complex amplitude ratio less than 0.95, the corresponding specificity was only 50%. However, if the abnormal cdtedon was defined as less than 0.80, the corresponding sensitivity was 60%, and the specificity was 97%. If the abnormal criterion of CHAMP was defined as latency delay less than 0.6 ms or the complex amplitude ratio less than 0.80, CHAMP result can be obtained in all subjects with good sensitivity and specificity. Conclusions CHAMP can differentiate patients with Meniere＇s disease from otologically normal subjects with high sensitivity and specificity. The recommended cdterion of abnormal CHAMP was a latency delay less than 0.6 ms or a complex amplitude ratio less than 0.80.

关 键 词：auditory evoked potentials diagnostic techniques Meniere＇s disease 

分 类 号：O661.1[理学—分析化学] TS736[理学—化学]