乙型肝炎病毒母婴垂直传播机制及阻断的研究进展  

Research progress in understanding the mechanisms and interruption of vertical transmission of hepatitis B virus

作　　者：黄燕武[1] 尹俊丰[1] 韩凤娟[1] 

机构地区：[1]解放军第536医院传染科,西宁810007

出　　处：《临床肝胆病杂志》2012年第12期959-960,I0001,共3页Journal of Clinical Hepatology

摘　　要：慢性乙型肝炎患者感染HBV的主要途径为母婴传播,母婴传播的机制不完全明确。阻断母婴传播的措施应该贯穿从孕前到婴儿出生后的全过程,HBsAg阳性孕妇娩出的新生儿应在24 h内尽早进行主-被动联合免疫,以尽可能减少围产期感染及哺乳期感染,乙型肝炎高病毒载量（≥10~6IU/ml）孕期应抗病毒治疗,以降低宫内传播的发生率。Vertical transmission is the main route of hepatitis B virus（HBV） infection in patients with chronic hepatitis B（CHB）.However, the mechanisms underlying the vertical transmission process remain to be fully elucidated.Measures to prevent mother - to - child transmission should be carried out during gestation,delivery,and the postnatal period.In order to reduce perinatal transmission and postnatal transmission through infected breast milk,newborns whose mothers tested positive for hepatitis B surface antigen（HBsAg） should be given active/passive immunization within 24 hours of delivery.In order to reduce the incidence of intrauterine transmission,pregnant women with CHB（HBV DNA≥10~6 IU/ml） should be given antiviral treatment.

关 键 词：肝炎病毒 乙型 疾病传播 垂直 免疫 主动 免疫 被动法 

分 类 号：R512.62[医药卫生—内科学]