α1A受体阻滞剂在上尿路结石术后应用的临床研究  

Clinical Research of the Application of α1A Adrenergic Antagonist in Treatment Of the Upper Urinary Tract Calculi After Surgery

作　　者：毕晓方[1] 史云强[2] 钟一鸣[1] 李珲[1] 王春晖[1] 

机构地区：[1]昆明医科大学附属延安医院泌尿外科,云南昆明650051 [2]昆明医科大学第二临床学院,云南昆明650101

出　　处：《昆明医科大学学报》2012年第11期107-110,共4页Journal of Kunming Medical University

摘　　要：目的评价α1A受体阻滞剂在上尿路结石术后对残留结石排出的影响,及其对输尿管支架管综合症的改善作用.方法回顾性研究2008年6月至2011年8月,对延安医院128例上尿路结石患者采用输尿管镜治疗输尿管结石102例,经皮肾镜取石术治疗输尿管上段结石和肾结石26例,所有患者术后均留置D-J管,治疗组68例术后给给予坦索罗辛0.2 mg口服,对照组60例.观察残留结石的排除成功率、排除时间,2周后D-J管拔除前的下尿路症状、生活质量及疼痛改善的情况.结果坦索罗辛治疗组残留结石完全排出60例,对照组42例;与对照组比较,治疗组对下尿路症状的改善情况、生活质量评分、视觉模拟评分(VAS)均优于对照组(P<0.05).结论α1A受体阻滞剂对上尿路结石术后具有明确的辅助排出残留结石的作用,并能有效缓解输尿管支架管综合症,改善患者术后的生活质量,值得临床上推广应用.Objective To evaluate the beneficial effect of α1A adrenergic antagonist for residual calculi and Ureteric Stent Symptom（USS）of upper urinary tract calculi on postope.Methods The data of 128 cases including 102 cases of medial and lower ureteral calculi who received ureteroscopic lithotripsy,and 26 cases of upper ureteral calculi or renal calculi who received percutaneous nephrostolithotomy from June 2008 to August 2011 were reviewed.All patients were given insertion of a double-J ureteral stent after operation and divided into two groups： control group（60 cases）and tamsulosin treatment group（68 cases）.The expulsion rate,expulsion time,lower urinary tract symptom before D-J tube removed in 2 weeks,quality of life（QOL）and 10-cm linear visual analogue scale（VAS）were observed.Results There were 60 cases with successful expulsion in tamsulosin treatment group and 42 cases with successful expulsion in control group.Comapred with control group,Tamsulosin treatment group showed obvious advantage in improving lower urinary tract symptom,QOL and VAS（P0.05）.Conclusions α1A adrenergic antagonist can increase the expulsion rate of on postope,release USS and improve quality of life,and should be added to the first-line adjunctive medical approach for treating upper urinary tract calculi.

关 键 词：Α1A受体阻滞剂 尿石症 治疗 

分 类 号：R691.4[医药卫生—泌尿科学]