新型醛基化海藻酸钠抗凝血涂层物制备及性能评价  

Preparation and Evaluation of Novel Anticoagulant Coating Material with Aldehyde Alginate

作　　者：李金友[1] 李彤[2] 高文卿[2] 于美丽[3] 胡晓旻[2] 许晋[2] 陆海滨[1] 于广栋[1] 

机构地区：[1]天津医科大学研究生院,天津300170 [2]天津市第三中心医院,天津300170 [3]天津市人工细胞重点实验室,天津300170

出　　处：《中国生物医学工程学报》2012年第6期918-924,共7页Chinese Journal of Biomedical Engineering

基　　金：天津市科技支撑计划重点项目(11ZCGYSY02000)

摘　　要：应用醛基化海藻酸钠交联涂层体外循环管路,并对涂层管路的血液相容性和生物相容性等性能进行研究和评价。将多醛基的氧化海藻酸钠(OSA),固定到体外循环聚氯乙烯(PVC)管路表面,评价其血液相容性和生物相容性等指标,并与空白对照组(PVCC)和进口产品美敦力肝素涂层组(PVCM)比较。结果表明,OSA涂层物有效固定在PVC管道表面,且OSA涂层管路(PVCS)具有良好的抗凝血性能,仅次于PVCM(P<0.05),显著优于PVCC(P<0.05);PVCS蛋白粘附率显著低于PVCC(P<0.05)和PVCM(P<0.05);PVCS血小板粘附量显著低于PVCC(P<0.05),与PVCM相比无显著差异(P>0.05)。PVCS与PVCM脱落率相比,有着相似的趋势。OSA涂层体外循环管路,具有良好的抗凝血性能、优越的生物相容性和较好的稳定性。This study is aimed to use oxidated sodium alginate（OSA）to coat medical polyvinyl chloride（PVC） pipe used for extracorporeal circulation,and evaluate the hemocompatibility and biocompatibility.The PVC pipe was coated with OSA.Its hemocompatibility and biocompatibility were evaluated and compared with those of PVCC and heparin-coated PVCM.The anticoagulant properties of oxidated sodium alginate coating group（PVCS）was lower than PVCM（P〈0.05）,but significantly better than that of PVCC（P〈0.05）.The protein adhesion of PVCS was significantly lower than that of the PVCC（P〈0.05） and PVCM（P〈0.05）.The platelet adhesion of PVCS was significantly lower than that of PVCC（P〈0.05）,but had no significantly difference from that of PVCM（P〈0.05）.The expulsion rates of PVCS had a similar tendency to that of PVCM in 72 hours.CONCLUSION： The PVCS coating improved biocompatibility,anticoagulant property and stability of PVC.

关 键 词：醛基化海藻酸钠 PVC管路 体外循环 抗凝血性能 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]