Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers  

作　　者：Chang-chun Haoa Run-guang Sun Jing Zhang 

机构地区：[1]College of Physics and Information Technology, Shaanxi Normal University, Xi'an 710052, China [2]College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062,China

出　　处：《Chinese Journal of Chemical Physics》2012年第6期691-696,I0004,共7页化学物理学报（英文）

摘　　要：Lipid rafts are a dynamic microdomain structure found in recent years, enriched in sphin- golipids, cholesterol and particular proteins. The change of structure and function of lipid rafts could result in many diseases. In this work, the monolayer miscibility behavior of mixed systems of Egg-Sphingomyelin （ESM） with 1, 2-dioleoyl-sn-glycero-3-phosphocholine was in- vestigated in terms of mean surface area per molecule and excess molecular area AAex at certain surface pressure, surface pressure and excess surface pressure Arcex at certain mean molecular area. The stability and compressibility of the mixed monolayers was assessed by the parameters of surface excess Gibbs free energy AGex, excess Helmholtz energy AHex and elasticity. Thermodynamic analysis indicates AAex and ATrex in the binary systems with positive deviations from the ideal behavior, suggesting repulsive interaction. The max- imum of AGex and AHex was at the molar fraction of ESM of 0.6, demonstrating the mixed monolayer was more unstable. The repulsive interaction induced phase separation in the monolayer.

关 键 词：MONOLAYER Attractive and repulsive interaction Stability Phase separation 

分 类 号：O484.1[理学—固体物理] TQ028.15[理学—物理]