依达拉奉对重型弥漫性轴索损伤神经功能恢复的影响  

EFFECT OF EDARAVONE ON NEUROLOGIC FUNCTIONAL REHABILITATION OF DIFFUSE AXONAL INJURY

作　　者：吴志宝 孙彦平 杨秀英 孙国柱[2] 

机构地区：[1]河北省定州市第七人民医院神经外科,河北定州073000 [2]河北医科大学第二医院神经外科,河北石家庄050000

出　　处：《河北医科大学学报》2012年第12期1389-1391,共3页Journal of Hebei Medical University

摘　　要：目的探讨依达拉奉对患者弥漫性轴索损伤(diffuse axonal injury,DAI)的促醒作用及对神经功能恢复的影响。方法将弥漫性轴索损伤患者70例随机分为2组,对照组和治疗组各35例。对照组给予止血、脱水、促醒、营养神经、维持水电解质平衡、营养支持、控制血糖和防治相关并发症等常规治疗。治疗组在常规治疗的基础上加用依达拉奉30mg静脉滴注,2次/d,共14d。2组患者均于治疗前,治疗7、14d后分别进行神经功能缺损程度评定和临床疗效评定。2组患者均随访3个月,分别观察比较2组清醒率、清醒时间。结果与对照组相比,治疗组神经功能程度评分、清醒率及清醒时间明显优于对照组,差异有统计学意义(P<0.05)。结论依达拉奉能够缩短弥漫性轴索损伤患者的昏迷时间,提高清醒率,促进神经功能康复。Objective To explore the awakening effect and neurologic functional rehabilitation of edaravone on patients with diffuse axonal injury （DAI）. Methods Seventy patients with DAI were randomly divided into treatment group and control group with 35 cases in each group. The control group was given hemostasis, dehydvation, awaking neurotrophie, maintaining water and eleetrdyte blance, netritional support, control of blood sugar and prevention of complications and other conventional treatment. The treatment group was administered edaravone, 30mg of which was intravenously infused 2 times per day for 14 days, in addition to the conventional therapy of the control group. Before treatment, and 7 days, 14 days after treatment, the degree of neural function defect and clinical efficacy evaluation were, performed in patients of two groups. All the patients were followed up for 3 months, and the awake rate and awake time were compared. Results Neural function defect score, awakening rate and awakening time of the treatment group were better than those in control group and there was statistically significant difference between the two groups （ P 〈 0.05 ）. Conclusion Edaravone can shorten coma time, increase awakening rate and improve neural function rehabilitation of the patients with diffuse axonal injury.

关 键 词：弥漫性轴索损伤 依达拉奉 功能恢复 

分 类 号：R651.15[医药卫生—外科学]